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Title: | Overexpression of cyclooxygenase-2 as a biomarker in different subtypes of the oral lichenoid disease |
Authors: | Cortes-Ramirez, Dionisio Alejandro Gainza-Cirauqui, Maria Luisa Aguirre-Urizar, Jose Manuel Rodriguez-Tojo, Maria J. Martinez-Conde, Rafael |
Keywords: | Clinical Enzyme Tests Clinical enzymology Mouth -- Diseases -- Diagnosis Inflammation -- Immunological aspects |
Issue Date: | 2010 |
Citation: | Cortés-Ramírez, D.A., Rodríguez-Tojo, M.J., Gainza-Cirauqui, M.L., Martínez-Conde, R., & Aguirre-Urizar, J.M. (2010). Overexpression of cyclooxygenase-2 as a biomarker in different subtypes of the oral lichenoid disease. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology, 110(6), 738-743. |
Abstract: | Objective. Oral lichenoid disease (OLD) includes a number of chronic inflammatory processes including oral lichen planus (OLP) and oral lichenoid lesions (OLL) with controversial diagnosis and prognosis. Cyclooxygenase-2 (COX-2) is a key enzyme for inflammatory processes and cellular proliferation. Its overexpression in some premalignant chronic inflammatory diseases and malignant neoplasias could point to its potential as a prognostic factor. The aim of this study was to analyze the COX-2 expression in different subtypes of OLD because of its potential to be a marker of altered behavior. Study design. Forty-four samples from OLD patients were studied (30 females and 14 males) and classified according to their clinical (C1: only papular lesions/C2: papular and other lesions) and histological features (HT: OLP typical/HC: OLP compatible) according to published criteria. Standard immunohistochemical procedure was performed for COX-2 expression and a comparative and descriptive statistical analyses were performed. Results. Epithelial COX-2 overexpression was observed in 24 (54.5%) cases (C1: 13 [54.2%]/C2: 11 [45.8%], HT: 9 [37.5%]/HC: 15 [62.5%], P .032). Inflammatory COX-2 overexpression was observed in 14 (31.8%) cases (C1: 6 [42.9%]/C2: 8 [57.1%], HT: 4 [28.6%]/HC: 10 [71.4%], P .032). Conclusion. Differences in COX-2 expression in subtypes of OLD may distinguish cases with a higher premalignant potential. |
Description: | This article was presented partially at the 9th Biennal Congress of the European Association of Oral Medicine, Salzburg, Austria, 2008. |
URI: | https://www.um.edu.mt/library/oar//handle/123456789/16300 |
Appears in Collections: | Scholarly Works - FacDenDS |
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Overexpression of cyclooxygenase-2 as a biomarker in different subtypes of the oral lichenoid disease.pdf Restricted Access | 1.09 MB | Adobe PDF | View/Open Request a copy |
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