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DC Field | Value | Language |
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dc.contributor.author | Pisani, David | - |
dc.contributor.author | Paris, Etienne Mark | - |
dc.contributor.author | Caruana Dingli, Gordon | - |
dc.date.accessioned | 2015-02-20T14:25:18Z | - |
dc.date.available | 2015-02-20T14:25:18Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Malta Medical Journal. 2014, Vol.26(2), p. 10-14 | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/1636 | - |
dc.description.abstract | Introduction: Obesity is a growing problem in the Western world. Correlations have been found between increasing body mass index (BMI) and breast cancer. The objectives were to establish whether a relationship exists between BMI and breast cancer and to investigate any association between BMI and tumour oestrogen receptor expression. Method: Clinical and socio-demographic details (age, menopausal status, height and weight) of a sample of women with breast cancer operated in 2010 were collected, dividing the group into oestrogen receptor positive (ER+) and negative (ER–) subgroups. The average BMI of each subgroup was compared to the mean BMI of a sample of the general Maltese female population obtained from the European Health Examination Survey 2010 Report (Pilot Study) by virtue of an ANOVA test. Subsequently, the relations between oestrogen receptor expression and each of menopausal status, age and BMI were statistically analysed using chi-squared analysis and two-sample t-tests. Results: A total of 103 patients were studied. 72 patients (age range: 40 – 90 years) had ER+ malignancy and 31 patients (29 – 81 years) had ER- malignancy. The mean BMI’s of the ER+ and ER- subgroups were 30.1 and 27.1 respectively, while that of the female general population (29 – 90 years) was 28.4. Analysis revealed a significant difference between the BMI’s of the ER+ and ER- subgroups (p<0.05) but no difference between each receptor subgroup and the general population. Neither menopausal status nor age was found to correlate with positive oestrogen receptor expression. Conclusions: Women with ER+ malignancy tended to be significantly more obese than those with ER- breast cancer. However, neither subgroup had a mean BMI significantly different from that of the general population. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Malta Medical Journal | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Breast -- Cancer | en_GB |
dc.subject | Obesity in women | en_GB |
dc.subject | Estrogen -- Receptors | en_GB |
dc.subject | Obesity in women -- Breast -- Cancer | en_GB |
dc.title | Relation between obesity and the oestrogen receptor status of breast cancer | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this article belongs to the Editorial Board of the Malta Medical Journal. The Malta Medical Journal’s rights in respect of this work are as defined by the Copyright Act (Chapter 415) of the Laws of Malta or as modified by any successive legislation. Users may access this full-text article and can make use of the information contained in accordance with the Copyright Act provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. This article has been reproduced with the authorization of the editor of the Malta Medical Journal (Ref. No 000002). | en_GB |
dc.description.reviewed | peer-reviewed | - |
Appears in Collections: | MMJ, Volume 26, Issue 2 MMJ, Volume 26, Issue 2 Scholarly Works - FacM&SSur |
Files in This Item:
File | Description | Size | Format | |
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2014.Vol26.Issue2.A2.pdf | Relation between obesity and the oestrogen receptor status of breast cancer | 1.09 MB | Adobe PDF | View/Open |
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