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Title: | Changes in bone collagen markers and in bone density in hormone treated and untreated postmenopausal women |
Authors: | Galea, Raymond P. Muscat Baron, Yves Brincat, Max P. Xuereb, Angela |
Keywords: | Menopause Menopause -- Hormone therapy Osteoporosis Bone densitometry |
Issue Date: | 1997 |
Publisher: | Elsevier Science Ireland Ltd. |
Citation: | Brincat, M., Galea, R., Muscat Baron, Y., & Xuereb, A. (1997). Changes in bone collagen markers and in bone density in hormone treated and untreated postmenopausal women. Maturitas, 27 (2), 171-177. |
Abstract: | This study aims to compare bone mineral density measurements (BMD), pyridinium crosslink levels and pyridinium crosslink levels in untreated and hormone treated postmenopausal women. Methods: A cross-sectional study comparing biophysical (BMD) and biochemical (pyridinium crosslink and PCICP) parameters in a group of untreated postmenopausal women (n=145) to a group of postmenopausal women on hormone replacement therapy (HRT) (n=92). Results: Untreated postmenopausal women compared to postmenopausal women on HRT had higher Osteoblastic and Osteoclastic activity. Procollagen I C-end terminal peptide (PCICP) was 11.3% lower in the women on HRT compared to controls whilst crosslinks were 27.2% lower than in controls. This seems to indicate that women on HRT had a bone balance that was higher compared to the control group (15.9%). The difference in bone density of L2–L4 between the two groups was (16.1%). Conclusions: This study seems to indicate that postmenopausal women receiving HRT readjust their bone remodelling so that although osteoblastic function is reduced, there is a much greater deduction in osteoclastic function and this results in an overall higher bone mass observed in the BMD of women on HRT. |
URI: | https://www.um.edu.mt/library/oar//handle/123456789/17263 |
Appears in Collections: | Scholarly Works - FacHScABS Scholarly Works - FacM&SOG |
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