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DC Field | Value | Language |
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dc.contributor.author | Attard, Everaldo | |
dc.contributor.author | Vella, Karin | |
dc.date.accessioned | 2017-06-14T12:59:10Z | |
dc.date.available | 2017-06-14T12:59:10Z | |
dc.date.issued | 2009-03-01 | |
dc.identifier.citation | Attard, E., & Vella, K. (2009). Effects of ephedrine and Ephedra fragilis crude extracts on human peripheral lymphocytes. Pharmacognosy Research, 1(2), 38. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/19885 | |
dc.description.abstract | Ephedra fragilis Desf. (Ephedraceae), a locally cultivated medicinal plant, is a source of ephedrine and pseudoephedrine, two important alkaloids, which have long played an important pharmacological role. The present study investigated the in vitro effects of ephedrine and the Ephedra branch extract on unstimulated lymphocytes. Ephedra alkaloids were extracted from various plant parts and after phytochemical analysis, the brine shrimp lethality test was used to determine the activity of the extracts. The LC 50 of the branch extract was 581.395 μg/ml, showing no statistical difference from that of ephedrine (208.203 μg/ml). The ephedrine and extract did not show toxic effects on lymphocytes but exhibited immunostimulant activity. Although ephedrine cannot be used as an immune booster, it can be used as a lead drug for further immunological research. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Medknow Publications | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Ephedrine | en_GB |
dc.subject | Interleukin-1 | en_GB |
dc.subject | Lymphocyte transformation | en_GB |
dc.subject | Cell proliferation | en_GB |
dc.title | Effects of ephedrine and Ephedra fragilis crude extracts on human peripheral lymphocytes | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
Appears in Collections: | Scholarly Works - InsESRSF |
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File | Description | Size | Format | |
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38_42_everlado.pdf Restricted Access | Main article | 295.23 kB | Adobe PDF | View/Open Request a copy |
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