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Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Hunter, Gary J. | |
dc.contributor.author | Vella, Marita | |
dc.contributor.author | Bonetta, Rosalin | |
dc.contributor.author | Farrugia, Diane | |
dc.contributor.author | Hunter, Therese | |
dc.date.accessioned | 2015-03-25T13:14:31Z | |
dc.date.available | 2015-03-25T13:14:31Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Xjenza. 2014, Vol.2(1), p. 42-47 | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/2014 | |
dc.description.abstract | Many people, including laymen, are aware of the double helical nature of the DNA molecule. A few may actually realise that it was the technique of X-ray crystallography that was the key to solving this structure. Even fewer will understand the uses and applications of crystallography to the most diverse of biological materials; proteins. In this review we discuss the application of a number of methodologies required to progress from a cloned gene to protein expression and purification, crystallisation conditions and eventually to X-ray structure determination. We provide our own experience in the field as examples of the procedures required. Protein crystallographers worldwide are contributing to our understanding of how enzymes work, how our immune system defends us against viruses and are using structural information to design novel pharmaceutical reagents. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Malta Chamber of Scientists | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | X-ray crystallography | en_GB |
dc.subject | Proteins | |
dc.title | The structure of protein molecules : in celebration of the International Year of Crystallography, 2014 | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.7423/XJENZA.2014.1.06 | |
Appears in Collections: | Scholarly Works - CenMMB Scholarly Works - FacM&SPB Xjenza, 2014, Volume 2, Issue 1 Xjenza, 2014, Volume 2, Issue 1 |
Files in This Item:
File | Description | Size | Format | |
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The Structure of Protein Molecules In Celebration of the International Year of Crystallography, 2014.pdf | 2.39 MB | Adobe PDF | View/Open |
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