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DC Field | Value | Language |
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dc.contributor.author | Pierucci, Massimo | - |
dc.contributor.author | Chambers, Stephanie | - |
dc.contributor.author | Partridge, Lucy | - |
dc.contributor.author | De Deurwaerdère, Philippe | - |
dc.contributor.author | Di Giovanni, Giuseppe | - |
dc.date.accessioned | 2017-10-13T14:44:35Z | - |
dc.date.available | 2017-10-13T14:44:35Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Pierucci, M., Chambers, S., Partridge, L., De Deurwaerdère, P., & Di Giovanni, G. (2014). Role of central serotonin receptors in nicotine addiction. In R. Lester (Ed.), Nicotinic receptors (pp. 279-305). New York: Humana Press. | en_GB |
dc.identifier.isbn | 9781493911660 | - |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/22558 | - |
dc.description.abstract | Regulation of normal or abnormal behaviour is critically controlled by the central serotonergic systems. Recent evidence has suggested that serotonin (5-HT) neurotransmission dysfunction contributes to a variety of pathological conditions, including depression, anxiety, schizophrenia and Parkinson’s disorders. There is also a great amount of evidence indicating that 5-HT signalling may affect the reinforcing properties of drugs of abuse by the interaction and modulation of dopamine (DA) function. This chapter is focused on one of the more addictive drugs, nicotine. It is widely recognised that the effects of nicotine are strongly associated with the stimulatory action it exhibits on mesolimbic DAergic function. We outline the role of 5-HT and its plethora of receptors, focusing on 5-HT2 subtypes with relation to their involvement in the neurobiology of nicotine addiction. We also explore the novel pharmacological approaches using 5-HT agents for the treatment of nicotine dependence. Compelling evidence shows that 5-HT2C receptor agonists may be possible therapeutic targets for smoking cessation, although further investigation is required. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Humana Press | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Nicotine | en_GB |
dc.subject | Receptor, Serotonin, 5-HT2C | en_GB |
dc.subject | Nicotine addiction -- Treatment | en_GB |
dc.subject | Smoking cessation | en_GB |
dc.subject | Serotonin | en_GB |
dc.subject | Parkinson's disease | en_GB |
dc.title | Role of central serotonin receptors in nicotine addiction | en_GB |
dc.title.alternative | Nicotinic receptors | en_GB |
dc.type | bookPart | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1007/978-1-4939-1167-7_14 | - |
Appears in Collections: | Scholarly Works - FacM&SPB |
Files in This Item:
File | Description | Size | Format | |
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Chapter 14 Nicotine and 5-HT.pdf | 527.91 kB | Adobe PDF | View/Open |
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