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DC Field | Value | Language |
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dc.contributor.author | Casarrubea, Maurizio | - |
dc.contributor.author | Davies, Caitlin | - |
dc.contributor.author | Faulisi, Fabiana | - |
dc.contributor.author | Pierucci, Massimo | - |
dc.contributor.author | Colangeli, Roberto | - |
dc.contributor.author | Partridge, Lucy | - |
dc.contributor.author | Chambers, Stephanie | - |
dc.contributor.author | Cassar, Daniel | - |
dc.contributor.author | Valentino, Mario | - |
dc.contributor.author | Muscat, Richard | - |
dc.contributor.author | Benigno, Arcangelo | - |
dc.contributor.author | Crescimanno, Giuseppe | - |
dc.contributor.author | Di Giovanni, Giuseppe | - |
dc.date.accessioned | 2017-10-13T17:11:03Z | - |
dc.date.available | 2017-10-13T17:11:03Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Casarrubea, M., Davies, C., Faulisi, F., Pierucci, M., Colangeli, R., Partridge, L...,Di Giovanni, G. (2015). Acute nicotine induces anxiety and disrupts temporal pattern organization of rat exploratory behavior in hole-board: a potential role for the lateral habenula. Frontiers in Cellular Neuroscience, 9, 197. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/22590 | - |
dc.description.abstract | Nicotine is one of the most addictive drugs of abuse. Tobacco smoking is a major cause of many health problems, and is the first preventable cause of death worldwide. Several findings show that nicotine exerts significant aversive as well as the well-known rewarding motivational effects. Less certain is the anatomical substrate that mediates or enables nicotine aversion. Here, we show that acute nicotine induces anxiogenic-like effects in rats at the doses investigated (0.1, 0.5, and 1.0 mg/kg, i.p.), as measured by the hole-board apparatus and manifested in behaviors such as decreased rearing and head-dipping and increased grooming. No changes in locomotor behavior were observed at any of the nicotine doses given. T-pattern analysis of the behavioral outcomes revealed a drastic reduction and disruption of complex behavioral patterns induced by all three nicotine doses, with the maximum effect for 1 mg/kg. Lesion of the lateral habenula (LHb) induced hyperlocomotion and, strikingly, reversed the nicotine-induced anxiety obtained at 1 mg/kg to an anxiolytic-like effect, as shown by T-pattern analysis. We suggest that the LHb is critically involved in emotional behavior states and in nicotine-induced anxiety, most likely through modulation of monoaminergic nuclei. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Frontiers Research Foundation | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Anxiety | en_GB |
dc.subject | Serotonin | en_GB |
dc.subject | Dopamine | en_GB |
dc.subject | Nicotine | en_GB |
dc.subject | Nicotine addiction | en_GB |
dc.title | Acute nicotine induces anxiety and disrupts temporal pattern organization of rat exploratory behavior in hole-board : a potential role for the lateral habenula | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.3389/fncel.2015.00197/full | - |
dc.publication.title | Frontiers in Cellular Neuroscience | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPB |
Files in This Item:
File | Description | Size | Format | |
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Casarrubea et al. 2015.pdf | 2.84 MB | Adobe PDF | View/Open |
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