Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/22761
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sardo, Pierangelo | - |
dc.contributor.author | Ferraro, Giuseppe | - |
dc.contributor.author | Di Giovanni, Giuseppe | - |
dc.contributor.author | Grutta, Vittorio La | - |
dc.date.accessioned | 2017-10-17T12:25:47Z | - |
dc.date.available | 2017-10-17T12:25:47Z | - |
dc.date.issued | 2003 | - |
dc.identifier.citation | Sardo, P., Ferraro, G., Di Giovanni, G., & La Grutta, V. (2003). Nitric oxide-induced inhibition on striatal cells and excitation on globus pallidus neurons: a microiontophoretic study in the rat. Neuroscience Letters, 343(2), 101-104. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/22761 | - |
dc.description.abstract | Single units were recorded in the striatum and in the globus pallidus (GP) of urethane-anesthetized rats under microiontophoretic administration of either Nω-nitro-l-arginine methyl ester (l-NAME, inhibitor of nitric oxide synthase), or 3-morpholino-sydnonimin-hydrocloride (SIN-1, nitric oxide, NO donor). A steady baseline firing of sporadically discharging striatal neurons (basal firing rate <0.1 spikes/s) was evoked by a pulsed microiontophoretic ejection of glutamate. On striatal neurons, microiontophoretic application of SIN-1 induced a current-dependent inhibition (11/13), whereas l-NAME administration produced a clear excitation (9/9). On GP cells, the administration of SIN-1 had excitatory effects (10/15), whereas the administration of l-NAME reduced the neuronal activity (6/6). We hypothesize that NO could exert an intrinsic regulatory action on the activity of both striatal and GP cells. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier Ireland Ltd. | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Basal ganglia | en_GB |
dc.subject | Nitric oxide | en_GB |
dc.subject | Globus pallidus | en_GB |
dc.title | Nitric oxide-induced inhibition on striatal cells and excitation on globus pallidus neurons : a microiontophoretic study in the rat | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1016/S0304-3940(03)00350-1 | - |
dc.publication.title | Neuroscience Letters | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPB |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
1-s2.0-S0304394003003501-main.pdf Restricted Access | 109.68 kB | Adobe PDF | View/Open Request a copy |
Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.