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DC Field | Value | Language |
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dc.contributor.author | Sardo, Pierangelo | - |
dc.contributor.author | Ferraro, Giuseppe | - |
dc.contributor.author | Di Giovanni, Giuseppe | - |
dc.contributor.author | Galati, Salvatore | - |
dc.contributor.author | La Grutta, Vittorio | - |
dc.date.accessioned | 2017-10-17T13:16:13Z | - |
dc.date.available | 2017-10-17T13:16:13Z | - |
dc.date.issued | 2002 | - |
dc.identifier.citation | Sardo, P., Ferraro, G., Di Giovanni, G., Galati, S., & La Grutta, V. (2002). Influence of nitric oxide on the spontaneous activity of globus pallidus neurones in the rat. Journal of Neural Transmission, 109(11), 1373-1389. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/22772 | - |
dc.description.abstract | Previous observations have suggested a role for nitric oxide in the activity of the globus pallidus, but this functional involvement has not yet been tested in vivo. The extracellular activity of single units of the globus pallidus was recorded, and neuronal nitric oxide synthase was inhibited by systemically administering 7-nitro-indazole to a group of anaesthetised rats. Forty-five per cent of cells responded with a decrease in the firing rate. In another group of rats, the microiontophoretic administration of 3-morpholino-sydnonimin-hydrocloride (a nitric oxide donor) induced an increase in neuronal firing rate (24/28 cells), whereas the administration of Nω-nitro-L-arginine methyl ester (a nitric oxide synthase inhibitor) reduced the activity of pallidal neurones (8/11 cells). No electrophysiological differences between drug-sensitive and -insensitive neurones were evidenced. An excitatory role of nitric oxide in controlling the level of spontaneous activity of globus pallidus neurones is suggested, without any influence upon the discharge pattern. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Springer Wien | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Rats as laboratory animals | en_GB |
dc.subject | Globus pallidus | en_GB |
dc.subject | NG-nitroarginine methyl ester | en_GB |
dc.title | Influence of nitric oxide on the spontaneous activity of globus pallidus neurones in the rat | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1007/s00702-002-0746-z | - |
dc.publication.title | Journal of Neural Transmission | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPB |
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