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Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/22774
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dc.contributor.authorPostorino, A.
dc.contributor.authorSerio, Rosa
dc.contributor.authorMule, Flava
dc.contributor.authorAdamo, E. B.
dc.contributor.authorDi Giovanni, Giuseppe
dc.contributor.authorMarini, Rolando
dc.date.accessioned2017-10-17T13:19:18Z
dc.date.available2017-10-17T13:19:18Z
dc.date.issued1993
dc.identifier.citationPostorino, A., Serio, R., Mule, F., Adamo, E. B., Di Giovanni, G., & Marini, R. (1993). Modulation of non-adrenergic non-cholinergic inhibitory transmission in rat duodenum : role of opiates and 5-hydroxytryptamine. Archives Italiennes de Biologie, 131, 235-243.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar//handle/123456789/22774
dc.description.abstractIn rat duodenal segments in vitro, electrical field stimulation induced a TTX-sensitive relaxation in the presence of atropine and guanethidine. A correlation between the amplitude of the evoked response and stimulus frequency was observed. Opioid peptides DAGO, DPDPE and DYN caused a dose-dependent increase in the amplitude of the response to EFS. Naloxone shifted to the right the dose-response curves for each opioid peptide significantly enhancing the ED50 values. The amplitude of the response to EFS was enhanced, dose-dependently, also in the presence of 5-HT. Such an effect induced by 5-HT was prevented by 5-HT receptor desensitization, but persisted unchanged after naloxone pretreatment. Opioids failed to affect the response to EFS after 5-HT receptor desensitization. Results suggest that in rat duodenum opioids modulate NANC inhibitory neurotransmission, indirectly the release of 5-HT.en_GB
dc.language.isoenen_GB
dc.publisherUniverista di Pisaen_GB
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_GB
dc.subjectReceptor, Serotonin, 5-HTen_GB
dc.subjectRats as laboratory animalsen_GB
dc.subjectOpioidsen_GB
dc.titleModulation of non-adrenergic non-cholinergic inhibitory transmission in rat duodenum : role of opiates and 5-hydroxytryptamineen_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.description.reviewedpeer-revieweden_GB
dc.publication.titleArchives Italiennes de Biologieen_GB
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