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https://www.um.edu.mt/library/oar/handle/123456789/22806
Title: | High dose of 8-OH-DPAT decreases maximal dentate gyrus activation and facilitates granular cell plasticity in vivo |
Authors: | Orban, Gergely Pierucci, Massimo Benigno, Arcangelo Pessia, Mauro Galati, Salvatore Valentino, Mario Muscat, Richard Di Giovanni, Giuseppe |
Keywords: | Temporal lobe epilepsy Dentate gyrus Serotonin Receptors, Serotonin Memory Depression, Mental |
Issue Date: | 2013 |
Publisher: | Springer |
Citation: | Orban, G., Pierucci, M., Benigno, A., Pessia, M., Galati, S., Valentino, M., Muscat, R., & Di Giovanni, G. (2013). High dose of 8-OH-DPAT decreases maximal dentate gyrus activation and facilitates granular cell plasticity in vivo. Experimental Brain Research, 230(4), 441-451. |
Abstract: | Although several studies have emphasized a crucial role for the serotonergic system in the control of hippocampal excitability, the role of serotonin (5-HT) and its receptors in normal and pathologic conditions, such as temporal lobe epilepsy (TLE), is still unclear. The present study was therefore designed firstly to investigate the acute effect of 8-OH-DPAT, a mixed 5-HT1A/7 receptor agonist, at a high dose (1 mg/kg, i.p.) known to have antiepileptic properties, in a model of acute partial epilepsy in rats. For this purpose, a maximal dentate activation (MDA) protocol was used to measure electrographic seizure onset and duration. In addition, the effect of 8-OH-DPAT on in vivo dentate gyrus cell reactivity and short- and long-term plasticity was studied. Rats injected with 8-OH-DPAT exhibited a significant reduction in MDA and epileptic discharges, a decrease in paired-pulse facilitation and an increase in long-term potentiation. This study suggests that 8-OH-DPAT or in general 5-HT1A/7 agonists might be useful for the treatment of TLE and also have some beneficial effects on the comorbid cognitive disorders seen in epileptic patients. |
URI: | https://www.um.edu.mt/library/oar//handle/123456789/22806 |
Appears in Collections: | Scholarly Works - FacM&SPB |
Files in This Item:
File | Description | Size | Format | |
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Orban et al EBR online.pdf | 3 MB | Adobe PDF | View/Open |
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