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Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/22809
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dc.contributor.authorPierucci, Massimo-
dc.contributor.authorDi Matteo, Vincenzo-
dc.contributor.authorBenigno, Arcangelo-
dc.contributor.authorCrescimanno, Giuseppe-
dc.contributor.authorEsposito, Ennio-
dc.contributor.authorDi Giovanni, Giuseppe-
dc.date.accessioned2017-10-18T08:58:16Z-
dc.date.available2017-10-18T08:58:16Z-
dc.date.issued2009-
dc.identifier.citationPierucci, M., Di Matteo, V., Beningo, A., Crescimanno, G., Esposito, E., & Di Giovanni, G. (2009). The unilateral nigral lesion induces dramatic bilateral modification on rat brain monoamine neurochemistry. Annals of the New York Academy of Sciences, 1155, 316-323.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar//handle/123456789/22809-
dc.description.abstract6-Hydroxydopamine (6-OHDA) is a neurotoxic compound commonly used to induce dopamine (DA) depletion in the nigrostriatal system, mimicking Parkinson's disease (PD) in animals. The aim of the present study was to evaluate the 7-day effect of unilateral nigral lesion on rat brain monoamine neurochemistry. Five brain regions were examined: the brain stem, cerebellum, hippocampus, striatum, and cortex. 6-OHDA-unilateral lesion dramatically modified DA, serotonin (5-HT) and their metabolites contents in both sides of the different brain nuclei. Furthermore, unilateral 6-OHDA lesion reduced DA and 5-HT contents and produced a robust inversion of their turnover in the nonlesioned side compared to sham-operated rats. These data suggest that 6-OHDA unilateral nigral lesion produces bilateral monoamine level modifications, and this piece of evidence should be taken into account when one interprets data from animal models of unilateral PD.en_GB
dc.language.isoenen_GB
dc.publisherWiley-Blackwell Publishing, Inc.en_GB
dc.rightsinfo:eu-repo/semantics/openAccessen_GB
dc.subjectParkinson's diseaseen_GB
dc.subjectRats as laboratory animalsen_GB
dc.subjectChromatography, High pressure liquiden_GB
dc.subjectBrain stemen_GB
dc.subjectCerebellumen_GB
dc.subjectCerebral cortexen_GB
dc.subjectHippocampus (Brain)en_GB
dc.subjectOxidopamineen_GB
dc.titleThe unilateral nigral lesion induces dramatic bilateral modification on rat brain monoamine neurochemistryen_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.description.reviewedpeer-revieweden_GB
dc.identifier.doi10.1111/j.1749-6632.2008.03679.x-
dc.publication.titleAnnals of the New York Academy of Sciencesen_GB
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