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DC Field | Value | Language |
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dc.contributor.author | Montefort, Stephen | |
dc.contributor.author | Goulding, David | |
dc.contributor.author | Polosa, Riccardo | |
dc.contributor.author | Haskard, Dorian O. | |
dc.contributor.author | Howarth, Peter Hugo | |
dc.contributor.author | Holgate, Stephen T. | |
dc.contributor.author | Carroll, Mary P. | |
dc.contributor.author | Gratziou, Christina G. | |
dc.date.accessioned | 2017-10-20T07:41:09Z | |
dc.date.available | 2017-10-20T07:41:09Z | |
dc.date.issued | 1994 | |
dc.identifier.citation | Montefort, S., Gratziou, C., Goulding, D., Polosa, R., Haskard, D. O., Howarth, P. H.,...Carroll, M. P. (1994). Bronchial biopsy evidence for leukocyte infiltration and upregulation of leukocyte-endothelial cell adhesion molecules 6 hours after local allergen challenge of sensitized asthmatic airways. Journal of Clinical Investigation, 93(4), 1411-1421. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/22876 | |
dc.description | This work was supported by a Medical Research Council Programme grant (PG 860 4034). S. Montefort is a Commonwealth Scholar. | en_GB |
dc.description.abstract | We have examined the mucosal changes occurring in bronchial biopsies from six atopic asthmatics 5-6 h after local endobronchial allergen challenge and compared them with biopsies from saline-challenged segments from the same subjects at the same time point. All the subjects developed localized bronchoconstriction in the allergen-challenged segment and had a decrease in forced expiratory volume in 1 s (FEV1) (P < 0.01) and a decrease in their methacholine provocative concentration of agonist required to reduce FEV1 from baseline by 20% (P < 0.05) 24 h postchallenge. At 6 h we observed an increase in neutrophils (P = 0.03), eosinophils (P = 0.025), mast cells (P = 0.03), and CD3+ lymphocytes (P = 0.025), but not in CD4+ or CD8+ lymphocyte counts. We also detected an increase in endothelial intercellular adhesion molecule type 1 (P < 0.05) and E-selectin (P < 0.005), but not vascular cell adhesion molecule type 1 expression with a correlative increase in submucosal and epithelial LFA+ leucocytes (P < 0.01). Thus, in sensitized asthmatics, local endobronchial allergen instillation leads to an increased inflammatory cell infiltrate of the airway mucosa that involves upregulation of specific adhesion molecules expressed on the microvasculature. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | The American Society for Clinical Investigation | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Allergens | en_GB |
dc.subject | Asthma | en_GB |
dc.subject | Leucocytes | en_GB |
dc.subject | Endothelial cells | en_GB |
dc.subject | Cell adhesion molecules | en_GB |
dc.title | Bronchial biopsy evidence for leukocyte infiltration and upregulation of leukocyte-endothelial cell adhesion molecules 6 hours after local allergen challenge of sensitized asthmatic airways | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1172/JCI117118 | |
dc.publication.title | Journal of Clinical Investigation | en_GB |
Appears in Collections: | Scholarly Works - FacM&SMed |
Files in This Item:
File | Description | Size | Format | |
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Bronchial biopsy evidence for leukocyte infiltration and upregulation.pdf | 4.63 MB | Adobe PDF | View/Open |
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