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DC Field | Value | Language |
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dc.contributor.author | Sultana, Janet | |
dc.date.accessioned | 2017-10-24T10:23:27Z | |
dc.date.available | 2017-10-24T10:23:27Z | |
dc.date.issued | 2017 | |
dc.identifier.citation | Sultana, J. (2017). New safety information on Azithromycin. The Synapse : the Medical Professionals' Network, 16(3), 10. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/22980 | |
dc.description.abstract | In the last few years the scientific community was debating the safety of the widely used macrolide antibiotic, azithromycin, which is commonly prescribed for respiratory and urinary tract infections. Previously published observational studies examined the risk of cardiovascular outcomes with azithromycin use, but these studies had conflicting results. The first such study to be published, a cohort study using U.S. Medicaid data, found an increased risk of cardiovascular death with azithromycin use. This led the Food and Drug Association to issue a warning on the safety of azithromycin use, although the European Medicines Agency did not take a position on this issue. Subsequent studies, both in the U.S. and in Europe did not always observe a risk of cardiovascular adverse events. This was likely due to several factors. Some studies investigated the link between cardiovascular death and azithromycin use. However, cardiovascular death can be considered a rather ambiguous outcome .given that the concern with aZithromycin use should be ventricular arrhythmia specifically, based on the effect of macrolides on QT- interval prolongation. Cardiovascular death may be due to conditions unrelated to ventricular arrhythmia. It is therefore possible that the cardiovascular impact of azithromycin is over-estimated by using this general clinical outcome. Another important factor leading to variation among the published studies is the diversity in the underlying study populations. For example, a study conducted among persons with a lower socioeconomic status such as Medicaid beneficiaries may show a comparatively higher cardiovascular risk than a European population. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Medical Portals Ltd. | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Azithromycin | en_GB |
dc.subject | Antibacterial agents -- Physiological effect | en_GB |
dc.subject | Drugs -- Side effects | en_GB |
dc.subject | Macrolide antibiotics | en_GB |
dc.title | New safety information on Azithromycin | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.publication.title | The Synapse : the Medical Professionals' Network | en_GB |
Appears in Collections: | The Synapse, Volume 16, Issue 3 The Synapse, Volume 16, Issue 3 |
Files in This Item:
File | Description | Size | Format | |
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The Synapse 16_3 - A2.pdf | 255.49 kB | Adobe PDF | View/Open |
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