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DC Field | Value | Language |
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dc.contributor.author | Duca, Deborah | - |
dc.contributor.author | Farrugia, Claude | - |
dc.date.accessioned | 2017-10-31T09:55:41Z | - |
dc.date.available | 2017-10-31T09:55:41Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Duca, D., & Farrugia, C. (2016). Development and validation of HPLC-PDA assay method of frangula emodin. Mediterranean Journal of Chemistry, 5(2), 374-386. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/23152 | - |
dc.description.abstract | Frangula emodin, (1,3,8-trihydroxy-6-methyl-anthraquinone), is one of the anthraquinone derivatives found abundantly in the roots and bark of a number of plant families traditionally used to treat constipation and haemorrhoids. The present study describes the development and subsequent validation of a specific Assay HPLC method for emodin. The separation was achieved on a Waters Symmetry C18, 4.6 × 250 mm, 5 μm particle size, column at a temperature of 35 °C, with UV detection at 287 and 436 nm. An isocratic elution mode consisting of 0.1% formic acid and 0.01% trifluoroacetic acid as the aqueous mobile phase, and methanol was used. The method was successfully and statistically validated for linearity, range, precision, accuracy, specificity and solution stability. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Mediterranean Journal of Chemistry | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Anthraquinones | en_GB |
dc.subject | HPLC (Chromatography) | en_GB |
dc.subject | Ames test | en_GB |
dc.title | Development and validation of HPLC-PDA assay method of frangula emodin | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.13171/mjc52/016030217/duca | - |
dc.publication.title | Mediterranean Journal of Chemistry | en_GB |
Appears in Collections: | Scholarly Works - FacSciChe |
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File | Description | Size | Format | |
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401-1732-1-PB.pdf | 369.13 kB | Adobe PDF | View/Open |
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