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Title: | Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin (5HT 2A) receptors in older, healthy adults |
Authors: | Chow, Tiffany W. Mamo, David Uchida, Hiroyuki Graff- Guerrero, Ariel Houle, Sylvain Smith, Gwenn S. Pollock, Bruce G. Mulsant, Benoit H. |
Keywords: | Receptor, Serotonin, 5-HT2A Serotonin Antidepressants Depression, Mental Antipsychotic drugs |
Issue Date: | 2009 |
Publisher: | BioMed Central Ltd. |
Citation: | Chow, T. W., Mamo, D. C., Uchida, H., Graff-Guerrero, A., Houle, S., Smith, G. S., ... & Mulsant, B. H. (2009). Test-retest variability of high resolution positron emission tomography (PET) imaging of cortical serotonin (5HT 2A) receptors in older, healthy adults. BMC Medical Imaging, 9(1), 12. |
Abstract: | Background: Position emission tomography (PET) imaging using [18F]-setoperone to quantify cortical 5-HT2A receptors has the potential to inform pharmacological treatments for geriatric depression and dementia. Prior reports indicate a significant normal aging effect on serotonin 5HT2A receptor (5HT2AR) binding potential. The purpose of this study was to assess the test-retest variability of [18F]-setoperone PET with a high resolution scanner (HRRT) for measuring 5HT2AR availability in subjects greater than 60 years old. Methods: Six healthy subjects (age range = 65–78 years) completed two [18F]-setoperone PET scans on two separate occasions 5–16 weeks apart. Results: The average difference in the binding potential (BPND) as measured on the two occasions in the frontal and temporal cortical regions ranged between 2 and 12%, with the lowest intraclass correlation coefficient in anterior cingulate regions. Conclusion: We conclude that the test-retest variability of [18F]-setoperone PET in elderly subjects is comparable to that of [18F]-setoperone and other 5HT2AR radiotracers in younger subject samples. |
URI: | https://www.um.edu.mt/library/oar//handle/123456789/23579 |
Appears in Collections: | Scholarly Works - FacM&SPsy |
Files in This Item:
File | Description | Size | Format | |
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1471-2342-9-12.pdf | 220.44 kB | Adobe PDF | View/Open |
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