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Title: | Estimating endogenous dopamine levels at D2 and D3 receptors in humans using the agonist radiotracer [11C]-(+)-PHNO |
Authors: | Caravaggio, Fernando Nakajima, Shinichiro Borlido, Carol Remington, Gary Gerretsen, Philip Wilson, Alan Houle, Sylvain Menon, Mahesh Mamo, David Graff-Guerrero, Ariel |
Keywords: | Dopamine Schizophrenia Depression, Mental |
Issue Date: | 2014 |
Publisher: | Nature Publishing Group |
Citation: | Caravaggio, F., Nakajima, S., Borlido, C., Remington, G., Gerretsen, P., Wilson, A., ... & Graff-Guerrero, A. (2014). Estimating endogenous dopamine levels at D2 and D3 receptors in humans using the agonist radiotracer [11C]-(+)-PHNO. Neuropsychopharmacology, 39(12), 2769-2776. |
Abstract: | Using positron emission tomography (PET) and an acute dopamine depletion challenge it is possible to estimate endogenous dopamine levels occupying dopamine D2/3 receptors (D2/3R) in humans in vivo. Our group has developed [11C]-(+)-PHNO, the first agonist radiotracer with preferential in vivo affinity for D3R. Thus, the use of [11C]-(+)-PHNO offers the novel possibility of (i) estimating in vivo endogenous dopamine levels at D2/3R using an agonist radiotracer, and (ii) estimating endogenous dopamine levels at D3R in extrastriatal regions such as the substantia nigra, hypothalamus, and ventral pallidum. Ten healthy participants underwent a [11C]-(+)-PHNO PET scan under baseline conditions and another under acute endogenous dopamine depletion achieved via oral administration of alpha-methyl-para-tyrosine (64 mg/kg). [11C]-(+)-PHNO binding was sensitive to acute dopamine depletion, allowing in vivo estimates of endogenous dopamine in D2R-rich regions (caudate and putamen), mixed D2/3R-rich regions (ventral striatum and globus pallidus), and extrastriatal D3R-rich regions (hypothalamus and ventral pallidum). Dopamine depletion decreased self-reported vigor, which was correlated with the reduction in dopamine levels in the globus pallidus. [11C]-(+)-PHNO is a suitable radiotracer for use in estimating endogenous dopamine levels at D2R and D3R in neuropsychiatric populations. |
URI: | https://www.um.edu.mt/library/oar//handle/123456789/23611 |
Appears in Collections: | Scholarly Works - FacM&SPsy |
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File | Description | Size | Format | |
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Estimating_Endogenous_Dopamine_Levels_at_D2_and_D3.pdf | 805.14 kB | Adobe PDF | View/Open |
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