Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/23612
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dc.contributor.authorSakurai, Hitoshi-
dc.contributor.authorBies, Robert R.-
dc.contributor.authorStroup, Scott T.-
dc.contributor.authorKeefe, Richard S. E.-
dc.contributor.authorRajji, Tarek K.-
dc.contributor.authorSuzuki, Takefumi-
dc.contributor.authorMamo, David-
dc.contributor.authorPollock, Bruce G.-
dc.contributor.authorWatanabe, Koichiro-
dc.contributor.authorMimura, Masaru-
dc.contributor.authorUchida, Hiroyuki-
dc.date.accessioned2017-11-09T12:56:04Z-
dc.date.available2017-11-09T12:56:04Z-
dc.date.issued2012-
dc.identifier.citationSakurai, H., Bies, R. R., Stroup, S. T., Keefe, R. S., Rajji, T. K., Suzuki, T., ... & Uchida, H. (2012). Dopamine D2 receptor occupancy and cognition in schizophrenia: analysis of the CATIE data. Schizophrenia Bulletin, 39(3), 564-574.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar//handle/123456789/23612-
dc.description.abstractIntroduction: Antipsychotic drugs exert antipsychotic effects by blocking dopamine D2 receptors in the treatment of schizophrenia. However, effects of D2 receptor blockade on neurocognitive function still remain to be elucidated. The objective of this analysis was to evaluate impacts of estimated dopamine D2 receptor occupancy with antipsychotic drugs on several domains of neurocognitive function in patients with schizophrenia in the Clinical Antipsychotic Trials in Intervention Effectiveness (CATIE) trial. Methods: The dataset from the CATIE trial was used in the present analysis. Data were extracted from 410 subjects who were treated with risperidone, olanzapine, or ziprasidone, received assessments for neurocognitive functions (verbal memory, vigilance, processing speed, reasoning, and working memory) and psychopathology, and provided plasma samples for the measurement of plasma antipsychotic concentrations. D2 receptor occupancy levels on the day of neurocognitive assessment were estimated from plasma antipsychotic concentrations, using population pharmacokinetic analysis and our recently developed model. A multivariate general linear model was used to examine effects of clinical and demographic characteristics, including estimated D2 occupancy levels, on neurocognitive functions. Results: D2 occupancy levels showed significant associations with the vigilance and the summary scores. Neurocognitive functions, including vigilance, were especially impaired in subjects who showed D2 receptor occupancy level of >77%. Discussion: These findings suggest a nonlinear relationship between prescribed antipsychotic doses and overall neurocognitive function and vigilance. This study shows that D2 occupancy above approximately 80% not only increases the risk for extrapyramidal side effects as consistently reported in the literature but also increases the risk for cognitive impairment.en_GB
dc.language.isoenen_GB
dc.publisherOxford University Pressen_GB
dc.rightsinfo:eu-repo/semantics/openAccessen_GB
dc.subjectAntipsychotic drugsen_GB
dc.subjectCognition -- Data processingen_GB
dc.subjectDopamineen_GB
dc.subjectOlanzapineen_GB
dc.subjectRisperidoneen_GB
dc.subjectSchizophreniaen_GB
dc.titleDopamine D2 receptor occupancy and cognition in schizophrenia : analysis of the CATIE dataen_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holderen_GB
dc.description.reviewedpeer-revieweden_GB
dc.identifier.doi10.1093/schbul/sbr189-
dc.publication.titleSchizophrenia Bulletinen_GB
Appears in Collections:Scholarly Works - FacM&SPsy

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