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DC Field | Value | Language |
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dc.contributor.author | Tsuboi, Takashi | - |
dc.contributor.author | Bies, Robert R. | - |
dc.contributor.author | Suzuki, Takefumi | - |
dc.contributor.author | Mamo, David | - |
dc.contributor.author | Pollock, Bruce G. | - |
dc.contributor.author | Graff-Guerrero, Ariel | - |
dc.contributor.author | Mimura, Masaru | - |
dc.contributor.author | Uchida, Hiroyuki | - |
dc.date.accessioned | 2017-11-09T13:18:38Z | - |
dc.date.available | 2017-11-09T13:18:38Z | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Tsuboi, T., Bies, R. R., Suzuki, T., Mamo, D. C., Pollock, B. G., Graff-Guerrero, A., ... & Uchida, H. (2013). Hyperprolactinemia and estimated dopamine D2 receptor occupancy in patients with schizophrenia: analysis of the CATIE data. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 45, 178-182. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/23629 | - |
dc.description.abstract | Background Large-scale data are still lacking on the relationship between serum prolactin concentration and dopamine D2 receptor occupancy in patients with schizophrenia treated with antipsychotics. Methods The dataset from 481 subjects (risperidone, N = 172, olanzapine, N = 211, and ziprasidone, N = 98) who participated in Phase 1 of the Clinical Antipsychotic Trials in Intervention Effectiveness (CATIE) was used in the present analysis. Dopamine D2 receptor occupancy levels on the day of the measurement of serum prolactin level were estimated from plasma antipsychotic concentrations. A multivariate general linear model was used to examine effects of clinical and demographic characteristics, including estimated D2 occupancy levels, on serum prolactin concentrations. Individual subjects were divided into two groups, stratified by the presence of hyperprolactinemia. To evaluate the performance of this binary classification, sensitivity, specificity, and accuracy of consecutive cut-off points in the D2 occupancy were calculated. Results The multivariate general linear model revealed that estimated D2 occupancy levels had significant effects on serum prolactin concentrations while any other variables failed to show significant effects. The cut-off point associated with 0.5 or greater, in both sensitivity and specificity with the greatest accuracy, was 73% (sensitivity, 0.58; specificity, 0.68; accuracy = 0.64) (68–70% for risperidone, 77% for olanzapine, and 55% for ziprasidone.). Conclusion The threshold for hyperprolactinemia in D2 occupancy may lie somewhat on a lower side of the established therapeutic window with antipsychotics (i.e. 65–80%). This finding highlights the need for the use of the lowest possible dose to avoid this hormonal side effect in the treatment of schizophrenia. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier Inc. | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Serotonin | en_GB |
dc.subject | Dopamine | en_GB |
dc.subject | Receptor, Serotonin, 5-HT2C | en_GB |
dc.subject | Hyperprolactinemia | en_GB |
dc.subject | Schizophrenia | en_GB |
dc.title | Hyperprolactinemia and estimated dopamine D2 receptor occupancy in patients with schizophrenia : analysis of the CATIE data | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1016/j.pnpbp.2013.05.010 | - |
dc.publication.title | Progress in Neuro-Psychopharmacology and Biological Psychiatry | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPsy |
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Hyperprolactinemia_and_Estimated_Dopamine_D2_Recep.pdf | 297.94 kB | Adobe PDF | View/Open |
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