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dc.contributor.authorBosica, Giovanna-
dc.contributor.authorAbdilla, Roderick-
dc.date.accessioned2017-12-14T09:27:20Z-
dc.date.available2017-12-14T09:27:20Z-
dc.date.issued2016-
dc.identifier.citationBosica, G., & Abdilla, R. (2016). Aza-Michael mono-addition using acidic alumina under solventless conditions. Molecules, 21(6), 815-825. Highlighted in World Biomedical Frontiers at http://biomedfrontiers.org/cancer-2016-6-15/en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar//handle/123456789/24668-
dc.identifier.urihttp://biomedfrontiers.org/cancer-2016-6-15/-
dc.descriptionSupplementary information is highlighted in World Biomedical Frontiers at http://biomedfrontiers.org/cancer-2016-6-15/ [Attached document refers]-
dc.description.abstractAza-Michael reactions between primary aliphatic and aromatic amines and various Michael acceptors have been performed under environmentally-friendly solventless conditions using acidic alumina as a heterogeneous catalyst to selectively obtain the corresponding mono-adducts in high yields. Ethyl acrylate was the main acceptor used, although others such as acrylonitrile, methyl acrylate and acrylamide were also utilized successfully. Bi-functional amines also gave the mono-adducts in good to excellent yields. Such compounds can serve as intermediates for the synthesis of anti-cancer and antibiotic drugs.en_GB
dc.language.isoenen_GB
dc.publisherMDPI AGen_GB
dc.rightsinfo:eu-repo/semantics/openAccessen_GB
dc.subjectChemical reactionsen_GB
dc.subjectAza Compoundsen_GB
dc.subjectSolvent wastesen_GB
dc.subjectSolventsen_GB
dc.subjectAminesen_GB
dc.titleAza-Michael mono-addition using acidic alumina under solventless conditionsen_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.description.reviewedpeer-revieweden_GB
dc.identifier.doi10.3390/molecules21060815-
dc.publication.titleMoleculesen_GB
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