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Title: | Acyclic α-nitro ketones : a versatile class of α-functionalized ketones in organic synthesis |
Authors: | Ballini, Roberto Bosica, Giovanna Fiorini, Dennis Palmieri, Alessandro |
Keywords: | Nitro compounds Organic compounds -- Synthesis Acyclic acids |
Issue Date: | 2005 |
Publisher: | Pergamon Press |
Citation: | Ballini, R., Bosica, G., Fiorini, D., & Palmieri, A. (2005). Acyclic α-nitro ketones : a versatile class of α-functionalized ketones in organic synthesis. Tetrahedron, 61(38), 8971-8993. |
Abstract: | α-Nitro ketones are an emerging class of molecules in organic synthesis, due to the presence on two adjacent positions of the carbonyl group and the carbon–nitro group moiety, that offers a new reactivity pattern, peculiar to a-nitro ketones. However, α-nitro cycloalkanones and acyclic α-nitro ketones have unlike reactivities and are utilized differently. The ring cleavage, promoted by external or internal nucleophiles (zip reactions), represents the main behaviour of cyclic α-nitro ketones, and these retro-Claisen condensations have already been exhaustively reviewed, while this report is mainly devoted to provide a comprehensive coverage of the synthesis, reactivity and possible transformations of acyclic α-nitro ketones, as well as their utilization in several interesting synthetic applications. Some common reactivities of both cyclic and acyclic α-nitro ketones will be also reported. |
URI: | https://www.um.edu.mt/library/oar//handle/123456789/24892 |
Appears in Collections: | Scholarly Works - FacSciChe |
Files in This Item:
File | Description | Size | Format | |
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1-s2.0-S004040200501029X-main.pdf Restricted Access | 2.48 MB | Adobe PDF | View/Open Request a copy |
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