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dc.contributor.authorWilson, Jerry B.-
dc.contributor.authorWebber, Brooke B.-
dc.contributor.authorKutlar, Abdullah-
dc.contributor.authorReese, A. L.-
dc.contributor.authorMcKie, Virgil C.-
dc.contributor.authorLutcher, Charles Lawrence-
dc.contributor.authorFelice, Alex-
dc.contributor.authorHuisman, Titus Hendrik Jan-
dc.date.accessioned2018-03-16T11:02:13Z-
dc.date.available2018-03-16T11:02:13Z-
dc.date.issued1989-
dc.identifier.citationWilson, J. B., Webber, B. B., Kutlar, A., Reese, A. L., McKie, V. C., Lutcher, C. L.,...Huisman, T. H. J. (1989). Hb Evans or α262 (E11) Val→ Metβ2; an unstable hemoglobin causing a mild hemolytic anemia. Hemoglobin, 13(6), 557-566.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar//handle/123456789/28016-
dc.description.abstractStructural analysis of the α chain of the hemoglobin from a Caucasian female with a mild hemolytic anemia showed the presence of a variant with a Val→Met substitution at position α62. The valine at this position forms one of the contacts with heme and its replacement by methionine will likely decrease heme binding and cause a distortion of the heme crevice and a decreased stability of the abnormal protein. Dot-blot analysis of amplified DNA with 32P-labeled synthetic oligonucleotide probes confirmed the suspected G→A mutation in the first position of codon 62, and also located the mutation in the α2-globin gene. The mutation was found in the proposita and one of her daughters but was most probably absent in her parents.en_GB
dc.description.sponsorshipThe authors are indebted to Dr. T.A. Stoming for his help in the synthesis of the oligonucleotide probes and to Mr. H. Hu for the partial sequence of the aT-9 peptide. This research was supported by USPHS Research Grants HLB-05168 and HLB-41544. This i s contribution #1172 from the Department o f Cell and Molecular Biology at the Medical College of Georgia in Augusta, Georgia.en_GB
dc.language.isoenen_GB
dc.publisherTaylor & Francisen_GB
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_GB
dc.subjectHemoglobinopathyen_GB
dc.subjectHemolytic anemiaen_GB
dc.subjectHemoglobin -- Case studiesen_GB
dc.subjectHemoglobins, Abnormalen_GB
dc.titleHb Evans or α262 (E11) Val→ Metβ2 ; an unstable hemoglobin causing a mild hemolytic anemiaen_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.description.reviewedpeer-revieweden_GB
dc.identifier.doi• 10.3109/03630268908993106-
dc.publication.titleHemoglobinen_GB
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