Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/28025| Title: | Detection and quantitation of the fetal hemoglobin variant Hb F-Malta-I in adults |
| Authors: | Altay, Gultekin Garver, Fred A. Bannister, William H. Grech, Joseph L. Huisman, Titus Hendrik Jan Felice, Alex |
| Keywords: | Fetal hemoglobin Hemoglobin polymorphisms Hemoglobin -- Malta |
| Issue Date: | 1977 |
| Publisher: | Springer |
| Citation: | Altay, G., Garver, F., Bannister, W. H., Grech, J. L., Felice, A., & Huisman, T. H. J. (1977). Detection and quantitation of the fetal hemoglobin variant Hb F-Malta-I in adults. Biochemical Genetics, 15(9-10), 915-923. |
| Abstract: | A variant of fetal hemoglobin (Hb F-Malta-I) has been detected and quantitated in adult blood with a sensitive radioimmunoassay employing monospecific anti-sera. The concentration of Hb F-Malta-I was 0.002-0.05%, with an average value of 0.011%. The ratio of Hb F-Malta-I/Hb F in adults was about 4.8%, compared to a ratio of about 27% in the newborn. Since the F-Malta-I variant is a product of a mutated Gγ locus, which is one of the nonallelic structural genes directing the γ chain synthesis, its presence in blood of adults shows that the synthesis of this gene is not completely suppressed after birth, as was previously suggested. |
| URI: | https://www.um.edu.mt/library/oar//handle/123456789/28025 |
| Appears in Collections: | Scholarly Works - FacM&SPB |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Detection_and_quantitation_of_the_fetal_hemoglobin_variant_Hb_F-Malta-I_in_adults_1977.pdf Restricted Access | 417.49 kB | Adobe PDF | View/Open Request a copy |
Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.