Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/28066
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dc.date.accessioned2018-03-20T07:21:46Z
dc.date.available2018-03-20T07:21:46Z
dc.identifier.citationGatt L., Schembri-Wismayer P., & Zammit-Mangion M. Investigation of the cyclooxygenase inhibition by polyphenol extracts derived from monocultivar oils from olive tree varieties from the Maltese islands. University of Malta, 1.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar//handle/123456789/28066
dc.description.abstractCyclooxygenase (COX) is the enzyme responsible for the conversion of twenty carbon fatty acids such as arachidonic acid (AA) into prostaglandins (PGs). In humans, PGs play a role in various important processes such as inflammation, labour initiation, kidney function and blood clotting (Dubois et al., 1998). Today it is recognised that inflammation plays an important role in leading to numerous other diseases, such as cancer (Rakoff-Nahoum, 2007). Hence there is interest in modulating this pathway through natural means. Two isoforms of the enzyme exist, these being COX-1 and COX-2. While the two are similar in primary protein structure and in the catalytic reaction they perform, they differ in their tissue expression patterns, inhibitor selectivity and in the substrates they utilise. Moreover, while COX-1 is constitutive, COX-2 is inducible (Vane et al., 1998). Non steroidal anti-inflammatory drugs (NSAIDs) inhibit COX, resulting in a decline in PG formation. Though greatly beneficial, NSAIDs cause renal and gastrointestinal side effects, such as damage to the mucosa and ulceration (Hawkey, 2001). In this study, the inhibition of COX by polyphenols extracted from autochtonous Maltese olive oil varieties was investigated.en_GB
dc.language.isoenen_GB
dc.publisherUniversity of Malta. Faculty of Medicine & Surgeryen_GB
dc.rightsinfo:eu-repo/semantics/openAccessen_GB
dc.subjectOlive oil -- Analysisen_GB
dc.subjectOlive -- Maltaen_GB
dc.subjectCyclooxygenasesen_GB
dc.titleInvestigation of the cyclooxygenase inhibition by polyphenol extracts derived from monocultivar oils from olive tree varieties from the Maltese islandsen_GB
dc.typeotheren_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holderen_GB
dc.description.reviewedN/Aen_GB
dc.contributor.creatorGatt, Lucienne
dc.contributor.creatorSchembri-Wismayer, Pierre
dc.contributor.creatorZammit-Mangion, Marion
Appears in Collections:Scholarly Works - FacM&SAna
Scholarly Works - FacM&SPB



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