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DC Field | Value | Language |
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dc.contributor.author | D'Adamo, Maria Cristina | - |
dc.contributor.author | Shang, Lijun | - |
dc.contributor.author | Imbrici, Paola | - |
dc.contributor.author | Brown, Steve D. M. | - |
dc.contributor.author | Pessia, Mauro | - |
dc.contributor.author | Tucker, Stephen J. | - |
dc.date.accessioned | 2018-03-26T12:18:42Z | - |
dc.date.available | 2018-03-26T12:18:42Z | - |
dc.date.issued | 2011 | - |
dc.identifier.citation | D'Adamo, M. C., Shang, L., Imbrici, P., Brown, S. D. M., Pessia, M., & Tucker, S. J. (2011). Genetic inactivation of Kcnj16 identifies Kir5.1 as an important determinant of neuronal PCO2/pH sensitivity. Journal of Biological Chemistry, 286(1), 192-198. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/28293 | - |
dc.description.abstract | The molecular identity of ion channels which confer PCO2/pH sensitivity in the brain is unclear. Heteromeric Kir4.1/Kir5.1 channels are highly sensitive to inhibition by intracellular pH and are widely expressed in several brainstem nuclei involved in cardiorespiratory control, including the locus coeruleus. This has therefore led to a proposed role for these channels in neuronal CO2 chemosensitivity. To examine this, we generated mutant mice lacking the Kir5.1 (Kcnj16) gene. We show that although locus coeruleus neurons from Kcnj16(+/+) mice rapidly respond to cytoplasmic alkalinization and acidification, those from Kcnj16(-/-) mice display a dramatically reduced and delayed response. These results identify Kir5.1 as an important determinant of PCO2/pH sensitivity in locus coeruleus neurons and suggest that Kir5.1 may be involved in the response to hypercapnic acidosis. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | The American Society for Biochemistry and Molecular Biology, Inc. | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Brain stem | en_GB |
dc.subject | Ion channels | en_GB |
dc.title | Genetic inactivation of Kcnj16 identifies Kir5.1 as an important determinant of neuronal PCO2/pH sensitivity | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1074/jbc.M110.189290 | - |
dc.publication.title | Journal of Biological Chemistry | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPB |
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Genetic_inactivation_of_Kcnj16_identifies_Kir5.1_2011.pdf Restricted Access | 1.1 MB | Adobe PDF | View/Open Request a copy |
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