ACE gene polymorphism as a prognostic indicator in patients with type 2 diabetes and established renal disease

Abstract

OBJECTIVE - To investigate whether the DD genotype is a predictor of mortality and of the decline in renal function in patients with type 2 diabetes and established nephropathy. RESEARCH DESIGN AND METHODS - A total of 56 such patients of Maltese Caucasian descent were recruited, and their ACE genotype was determined. Serum creatinine was estimated approximately every 4 months. The glomerular nitration rate (GFR) was calculated according to the Cockroft-Gault formula, and rate of change was determined by regression analysis. RESULTS - The rate of change in calculated GFR was -7.76 ml • min-1• year-1 in those with the DD genotype (n = 31) and -1.17 ml • min-1 • h-1 in those with the ID or II genotype (n = 25) (P < 0.01). The 3-year mortality was 45.2% in the DD group compared with 20.0% in the ID/11 group (P < 0.05). CONCLUSIONS - The DD genotype of the ACE gene polymorphism is associated with a more rapid decline in renal function and higher mortality in type 2 diabetic patients with established nephropathy.