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DC Field | Value | Language |
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dc.contributor.author | Palma, Giuseppe de | - |
dc.contributor.author | Dick, Finlay D. | - |
dc.contributor.author | Calzetti, Stefano | - |
dc.contributor.author | Scott, Neil W. | - |
dc.contributor.author | Prescott, Gordon James | - |
dc.contributor.author | Osborne, Aileen | - |
dc.contributor.author | Haites, Neva E. | - |
dc.contributor.author | Mozzoni, Paola | - |
dc.contributor.author | Negrotti, Anna | - |
dc.contributor.author | Scaglioni, Augusto | - |
dc.contributor.author | Mutti, Antonio | - |
dc.contributor.author | Felice, Alex | - |
dc.contributor.author | Bezzina Wettinger, Stephanie | en_GB |
dc.contributor.author | Borg, Joseph J. | - |
dc.contributor.author | Scerri, Christian A. | - |
dc.date.accessioned | 2018-04-09T08:18:18Z | - |
dc.date.available | 2018-04-09T08:18:18Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | De Palma, G., Dick, F. D., Calzetti, S., Scott, N. W., Prescott, G. J., Osborne, A.,...Mutti, A. (2010). A case‐control study of Parkinson's disease and tobacco use: gene‐tobacco interactions. Movement Disorders, 25(7), 912-919. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/28916 | - |
dc.description.abstract | A case-control study of genetic, environmental, and occupational risk factors for Parkinson’s disease (PD) was carried out in five European countries (Italy, Malta, Romania, Scotland, and Sweden) to explore the possible contribution of interactions among host and environmental factors in sporadic PD. Whereas smoking habits confirmed its negative association with PD, a possible modulatory role of genetic polymorphisms was investigated to obtain further mechanistic insights. We recruited 767 cases of PD and 1989 age-matched and gender-matched controls. Participants completed an interviewer-administered questionnaire including the history of smoking habits. The polymorphisms of genes involved either in metabolism of compounds contained in tobacco smoke (CYP2D6, CYP1B1, GSTM1, GSTT1, GSTM3, GSTP1, NQO1, SOD2, EPHX and NAT2) or in dopaminergic neurotransmission (MAOA, MAOB, DAT1 and DRD2) were characterized by PCR based methods on genomic DNA. We found evidence of statistically significant gene-tobacco interaction for GSTM1, NAT2, and GSTP1, the negative association between tobacco smoking and PD being significantly enhanced in subjects expressing GSTM1-1 activity, in NAT2 fast acetylators, and in those with the GSTP1*B*C haplotype. Owing to the retrospective design of the study, these results require confirmation. | en_GB |
dc.description.sponsorship | This study was funded by the European Union as part of the Fifth Framework program, project number QLK4-CT-1999-01133. We gratefully acknowledge the support of the European Union for this project. We wish to thank Professor Anthony Seaton CBE for his critical review of the manuscript. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Wiley Online Library | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Smoking -- Health aspects | en_GB |
dc.subject | Genetic polymorphisms | en_GB |
dc.subject | Parkinson's disease -- Case studies | en_GB |
dc.subject | Gene-environment interaction | en_GB |
dc.title | A case-control study of Parkinson’s disease and tobacco use : gene-tobacco interactions | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.contributor.corpauthor | Geoparkinson Study Group | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1002/mds.22980 | - |
dc.publication.title | Movement Disorders | en_GB |
Appears in Collections: | Scholarly Works - FacHScABS Scholarly Works - FacM&SPB |
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