The Kir5.1 potassium channel is an important determinant of neuronal PCO2/pH sensitivity

D'Adamo, Maria Cristina; Shang, Lijun; Imbrici, Paola; Brown, Steve D. M.; Pessia, Mauro; Tucker, Stephen J.

Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/29141

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DC Field	Value	Language
dc.contributor.author	D'Adamo, Maria Cristina	-
dc.contributor.author	Shang, Lijun	-
dc.contributor.author	Imbrici, Paola	-
dc.contributor.author	Brown, Steve D. M.	-
dc.contributor.author	Pessia, Mauro	-
dc.contributor.author	Tucker, Stephen J.	-
dc.date.accessioned	2018-04-13T14:17:37Z	-
dc.date.available	2018-04-13T14:17:37Z	-
dc.date.issued	2011	-
dc.identifier.citation	D'Adamo, M. C., Shang, L., Imbrici, P., Brown, S. D., Pessia, M., & Tucker, S. J. (2011). The Kir5. 1 potassium channel is an important determinant of neuronal PCO2/pH sensitivity. Biophysical Journal, 100(3), 430a.	en_GB
dc.identifier.uri	https://www.um.edu.mt/library/oar//handle/123456789/29141	-
dc.description.abstract	The molecular identity of ion channels which respond to PCO2/pH in the brain is still unclear. Heteromeric Kir4.1/Kir5.1 channels are highly sensitive to inhibition by intracellular pH and are widely expressed in several brainstem nuclei involved in cardiorespiratory control, including the locus coeruleus (LC). This has therefore led to a proposed role for these channels in neuronal CO2-chemosensitivity. In order to examine this we generated mutant mice lacking the Kir5.1 (Kcnj16) gene. We show that whilst LC neurons from Kcnj16(+/+) mice rapidly respond to cytoplasmic alkalinization and acidification, those from Kcnj16(−/−) mice display a dramatically reduced and delayed response.	en_GB
dc.language.iso	en	en_GB
dc.publisher	Elsevier	en_GB
dc.rights	info:eu-repo/semantics/restrictedAccess	en_GB
dc.subject	Potassium channels	en_GB
dc.title	The Kir5.1 potassium channel is an important determinant of neuronal PCO2/pH sensitivity	en_GB
dc.type	article	en_GB
dc.rights.holder	The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.	en_GB
dc.description.reviewed	peer-reviewed	en_GB
dc.identifier.doi	10.1016/j.bpj.2010.12.2539	-
dc.publication.title	Biophysical Journal	en_GB
Appears in Collections:	Scholarly Works - FacM&SPB

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