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DC Field | Value | Language |
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dc.contributor.author | Iacoviello, Licia | - |
dc.contributor.author | De Curtis, Amalia | - |
dc.contributor.author | Amore, Concetta | - |
dc.contributor.author | D'Adamo, Maria Cristina | - |
dc.contributor.author | Buczko, Wlodizimierz X. | - |
dc.contributor.author | De Gaetano, Giovanni | - |
dc.contributor.author | Donati, Maria Benedetta | - |
dc.date.accessioned | 2018-04-13T16:58:23Z | - |
dc.date.available | 2018-04-13T16:58:23Z | - |
dc.date.issued | 1992 | - |
dc.identifier.citation | Iacoviello, L., De Curtis, A., Amore, C., D'Adamo, M. C., Buczko, W., de Gaetano, G., & Donati, M. B. (1992). Effect of aspirin on the fibrinolytic response in perfused rat hindquarters. European Journal of Pharmacology, 229(1), 39-44. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/29188 | - |
dc.description.abstract | The role of aspirin in tissue plasminogen activator (t-PA) release was studied in rats after experimental venous occlusion. For this purpose, we developed a new experimental model which combines a vascular perfusion system (isolated rat hindquarters) with vascular stimulation, namely the application of venous stasis. Application of venous stasis for 30 min induced the release of t-PA from the vascular endothelium into the perfusate (from 0.19 ± 0.05 to 0.39 ± 0.05 UI/ml), reaching a peak 90 s after reperfusion. Aspirin administered to rats 60 min before the experiments (100 mg/kg i.v.), or dissolved in Tyrode solution (100 μM), suppressed 6-keto-prostaglandin F1α (6-keto-PGF1α) synthesis (0.38 ± 0.09 in control and <0.01 and 0.15 ± 0.09 ng/ml, respectively, in aspirin-treated groups) but did not prevent the increase in fibrinolytic activity after venous occlusion (from 0.20 ± 0.04 to 0.38 ± 0.06 and from 0.07 ± 0.03 to 0.27 ± 0.03 IU/ml, respectively, in the aspirin-treated group). Our results suggest that the increase in fibrinolytic activity after experimental venous occlusion in isolated rat hindlegs is modulated by mechanism(s) other than the cyclooxygenase pathway in the vascular wall. | en_GB |
dc.description.sponsorship | This work was partially supported by Italian National Research Council (Special Project 'FATMA' No. 910027941, 1990 and 1991). L.I. was the recipient of a fellowship from the Centro di Formazione e Studi per il Mezzogiorno - FORMEZ - (Progetto Speciale 'Ricerca Scientifica e Applicata nel Mezzogiorno'). C.A. and M.C.D. are the recipients of fellowships from the Regional Council of Abruzzo and the Commission of European Communities. The authors wish to thank Raffaella BertazzL Silvia Falcone, Maria Teresa Di Prospero and the G.A. Pfeiffer Memorial Library staff for their contribution in editing the manuscript. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Elsevier | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Aspirin | en_GB |
dc.subject | Fibrinolysis | en_GB |
dc.subject | Plasminogen activators | en_GB |
dc.title | Effect of aspirin on the fibrinolytic response in perfused rat hindquarters | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1016/0014-2999(92)90283-A | - |
dc.publication.title | European Journal of Pharmacology | en_GB |
Appears in Collections: | Scholarly Works - FacM&SPB |
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