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DC Field | Value | Language |
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dc.contributor.author | Wain, Louise V. | - |
dc.contributor.author | Bossini-Castillo, Lara | - |
dc.contributor.author | Portelli, Michael A. | - |
dc.contributor.author | Fenech, Anthony G. | - |
dc.date.accessioned | 2018-05-31T17:10:28Z | - |
dc.date.available | 2018-05-31T17:10:28Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Wain, L. V., Shrine, N., Artigas, M. S., Erzurumluoglu, A. M., Noyvert, B., Bossini-Castillo, L., ... & Billington, C. K. (2017). Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets. Nature Genetics, 49(3), 416. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/30675 | - |
dc.description.abstract | Chronic obstructive pulmonary disease (COPD) is characterized by reduced lung function and is the third leading cause of death globally. Through genome-wide association discovery in 48,943 individuals, selected from extremes of the lung function distribution in UK Biobank, and follow-up in 95,375 individuals, we increased the yield of independent signals for lung function from 54 to 97. A genetic risk score was associated with COPD susceptibility (odds ratio per 1 s.d. of the risk score (~6 alleles) (95% confidence interval) = 1.24 (1.20–1.27), P = 5.05 × 10−49), and we observed a 3.7-fold difference in COPD risk between individuals in the highest and lowest genetic risk score deciles in UK Biobank. The 97 signals show enrichment in genes for development, elastic fibers and epigenetic regulation pathways. We highlight targets for drugs and compounds in development for COPD and asthma (genes in the inositol phosphate metabolism pathway and CHRM3) and describe targets for potential drug repositioning from other clinical indications. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Nature Publishing Group | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Lungs -- Diseases, Obstructive | en_GB |
dc.subject | Disease susceptibility -- Genetic aspects | en_GB |
dc.subject | Genomes -- Analysis | en_GB |
dc.subject | Lungs -- Diseases | en_GB |
dc.title | Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1038/ng.3787 | - |
dc.publication.title | Nature Genetics | en_GB |
Appears in Collections: | Scholarly Works - FacM&SCPT |
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