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DC Field | Value | Language |
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dc.contributor.author | Friedman, Deborah M. | |
dc.contributor.author | Glickstein, J. | |
dc.contributor.author | Duncanson, L.J. | |
dc.contributor.author | Buyon, Jill P. | |
dc.date.accessioned | 2015-07-08T09:05:27Z | |
dc.date.available | 2015-07-08T09:05:27Z | |
dc.date.issued | 2003 | |
dc.identifier.citation | Images in Paediatric Cardiology. 2003, Vol.5(3), p. 36-48 | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar//handle/123456789/3940 | |
dc.description.abstract | Congenital heart block is a rare disorder. It has an incidence of about 1 in 22,000 live births. It may be associated with high mortality and morbidity. This should generate a high index of suspicion for early diagnosis and aggressive therapy when appropriate. The congenital heart block associated with neonatal lupus is considered a form of passively acquired autoimmune disease in which maternal autoantibodies to the intracellular ribonucleoproteins Ro (SS-A) and La (SS-B), cross the placenta and injure the previously normal fetal heart. Women with serum titers of anti-Ro antibody carry a 3% risk of having a child with neonatal lupus syndrome. Recurrence rates are about 18%. We believe that serial echocardiograms should be acquired so that early diagnosis is made and aggressive therapy administered, if signs of conduction system disease such as PR interval prolongation by Doppler are found, so as to optimize the outcome. Establishment of guidelines for therapy have been set empirically, should signs of congenital heart block develop. Those patients whose congenital heart block is associated with structural heart disease have a higher morbidity and mortality, which is determined more by the underlying structural congenital heart disease than it is by the need for a pacemaker per se. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Images in Paediatric Cardiology | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Heart block | en_GB |
dc.subject | Congenital heart disease | en_GB |
dc.title | A review of congenital heart block | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
Appears in Collections: | IPC, Volume 5, Issue 3 IPC, Volume 5, Issue 3 |
Files in This Item:
File | Description | Size | Format | |
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A review of congenital heart block.pdf | 1.66 MB | Adobe PDF | View/Open |
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