How and why we age : clinical implications

Abstract

If ageing is perceived as a disease, then there is the potential that we can cure it! But curing ageing entails understanding it. So far, understanding ageing has remained a challenge. However, observations and research, on model organisms and humans alike, are evolving fast. In this review, we will start with a discussion of both the damage and the programmed theories of ageing. Ultimately, we will focus on calorie restriction and telomere shortening and how these relate to lifespan extension.