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DC Field | Value | Language |
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dc.contributor.author | Brincat, Mark P. | - |
dc.contributor.author | Homburg, Roy R. | - |
dc.contributor.author | Hendriks, Marja Liisa | - |
dc.contributor.author | König, Tamar Elisabeth | - |
dc.contributor.author | Anderson, Richard A. A. | - |
dc.contributor.author | Balen, Adam H. | - |
dc.contributor.author | Child, Tim J. | - |
dc.contributor.author | Davies, Melanie C. | - |
dc.contributor.author | D'Hooghe, Thomas Maria | - |
dc.contributor.author | Martinez, A. | - |
dc.contributor.author | Rajkhowa, Madhurima | - |
dc.contributor.author | Rueda-Saenz, R. | - |
dc.contributor.author | Hompes, Peter GA | - |
dc.contributor.author | Lambalk, C. B.Nils | - |
dc.date.accessioned | 2019-08-21T09:28:25Z | - |
dc.date.available | 2019-08-21T09:28:25Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Homburg, R., Hendriks, M. L., König, T. E., Anderson, R. A., Balen, A. H., Brincat, M.P.,.... Lambalk, C.B. (2012). Clomifene citrate or low-dose FSH for the first-line treatment of infertile women with anovulation associated with polycystic ovary syndrome: a prospective randomized multinational study. Human Reproduction, 27(2), 468-473. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/45758 | - |
dc.description.abstract | BACKGROUND: Clomifene citrate (CC) is accepted as the first-line method for ovulation induction (OI) in patients with polycystic ovary syndrome (PCOS) associated with infertility owing to anovulation. Low-dose FSH has been reserved for women failing to conceive with CC. In this RCT, we tested the hypothesis that pregnancy rate (PR) and live birth rates (LBR) are higher after OI with low-dose FSH than with CC as first-line treatment. METHODS: Infertile women (<40 years old) with PCOS-related anovulation, without prior OI treatment, attending 10 centres in Europe/South America were randomized to OI with either CC (50-150 mg/day for 5 days) or FSH (starting dose 50 IU) for up to three treatment cycles. The primary outcome was clinical PR. RESULTS: Patients (n = 302) were randomized to OI with FSH (n = 132 women; 288 cycles) or CC (n = 123; 310 cycles). Per protocol analysis revealed that reproductive outcome was superior after OI with FSH than with CC with respect to PR per first cycle [30 versus 14.6%, respectively, 95 confidence interval (CI) 5.3-25.8, P = 0.003], PR per woman, (58 versus 44% of women, 95% CI 1.5-25.8, P = 0.03), LBR per woman (52 versus 39%, 95% CI 0.4-24.6, P = 0.04), cumulative PR (52.1 versus 41.2%, P = 0.021) and cumulative LBR (47.4 versus 36.9%, P = 0.031), within three cycles of OI. CONCLUSIONS: Pregnancies and live births are achieved more effectively and faster after OI with low-dose FSH than with CC. This result has to be balanced by convenience and cost in favour of CC. FSH may be an appropriate first-line treatment for some women with PCOS and anovulatory infertility, particularly older patients. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | Oxford Academic | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Infertility, Female -- Treatment | en_GB |
dc.subject | Polycystic ovary syndrome | en_GB |
dc.subject | Ovulation -- Induction | en_GB |
dc.subject | Follicle-stimulating hormone | en_GB |
dc.subject | Fertility Agents, Female | en_GB |
dc.title | Clomifene citrate or low-dose FSH for the first-line treatment of infertile women with anovulation associated with polycystic ovary syndrome : a prospective randomized multinational study | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1093/humrep/der401 | - |
dc.publication.title | Human Reproduction | en_GB |
Appears in Collections: | Scholarly Works - FacM&SOG |
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Clomifene_citrate_or_low-dose_FSH_for_the_first-line_treatment_of_infertile_women_with _anovulation_associated_with_polycystic_ovary_syndrome_2012.pdf | 267.76 kB | Adobe PDF | View/Open |
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