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https://www.um.edu.mt/library/oar/handle/123456789/48756| Title: | Drug design of de novo designed molecules at the peroxisome proliferator activated receptor |
| Authors: | Portelli, Stephanie Shoemake, Claire Azzopardi, Lilian M. |
| Keywords: | Drugs -- Design Peroxisomes -- Receptors Rosiglitazone Diabetes -- Treatment |
| Issue Date: | 2013-08 |
| Publisher: | University of Malta. Department of Pharmacy |
| Citation: | Portelli, S., Shoemake, C., & Azzopardi, L. M. (2013, August). Drug design of de novo designed molecules at the peroxisome proliferator activated receptor. Poster session presented at the International Pharmaceutical Federation (FIP) World Congress, Dublin, Ireland. |
| Abstract: | A poster presentation regarding drug design of de novo designed molecules at the peroxisome proliferator activated receptor. Introduction: Following rosiglitazone withdrawal, newer therapies aiming at the Peroxisome Proliferator Activated Receptor y (PPARγ) as treatment for type 2 diabetes acting mainly via partial agonism are being studied. Such partial agonists include selective PPARγ modulators such as S-26948. Aim: To obtain and optimise molecules having a high affinity to PPARγ, and which are also Lipinski Rule compliant. |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/48756 |
| Appears in Collections: | Scholarly Works - FacM&SPha |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Drug_design_of_de_novo_designed_molecules_at_the_peroxisome_proliferator_activated_receptor_2013.pdf | 1.24 MB | Adobe PDF | View/Open |
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