Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/49201
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dc.contributor.authorFarrugia, Gianluca-
dc.contributor.authorBalzan, Rena-
dc.date.accessioned2019-12-03T07:36:51Z-
dc.date.available2019-12-03T07:36:51Z-
dc.date.issued2013-
dc.identifier.citationFarrugia, G., & Balzan, R. (2013). The proapoptotic effect of traditional and novel nonsteroidal anti-inflammatory drugs in mammalian and yeast cells. Oxidative Medicine and Cellular Longevity, 1-18.en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar/handle/123456789/49201-
dc.description.abstractNonsteroidal anti-inflammatory drugs (NSAIDs) have long been used to treat pain, fever, and inflammation. However, mounting evidence shows that NSAIDs, such as aspirin, have very promising antineoplastic properties.The chemopreventive, antiproliferative behaviour of NSAIDs has been associated with both their inactivation of cyclooxygenases (COX) and their ability to induce apoptosis via pathways that are largely COX-independent. In this review, the various proapoptotic pathways induced by traditional and novel NSAIDs such as phospho-NSAIDs, hydrogen sulfide-releasing NSAIDs and nitric oxide-releasing NSAIDs in mammalian cell lines are discussed, as well as the proapoptotic effects of NSAIDs on budding yeast which retains the hallmarks of mammalian apoptosis. The significance of these mechanisms in terms of the role of NSAIDs in effective cancer prevention is considered.en_GB
dc.language.isoenen_GB
dc.publisherHindawi Publishing Corporationen_GB
dc.rightsinfo:eu-repo/semantics/openAccessen_GB
dc.subjectAnti-inflationary policiesen_GB
dc.subjectCyclooxygenasesen_GB
dc.subjectDrugs -- Effectivenessen_GB
dc.subjectMitochondrial DNAen_GB
dc.subjectCarcinogenesisen_GB
dc.titleThe proapoptotic effect of traditional and novel nonsteroidal anti-inflammatory drugs in mammalian and yeast cellsen_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holderen_GB
dc.description.reviewedpeer-revieweden_GB
dc.identifier.doi10.1155/2013/504230-
dc.publication.titleOxidative Medicine and Cellular Longevityen_GB
Appears in Collections:Scholarly Works - FacM&SPB



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