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https://www.um.edu.mt/library/oar/handle/123456789/49310
Title: | Tenofovir as rescue therapy following clinical failure to lamivudine in severe acute hepatitis B |
Authors: | Gerada, Jurgen Borg, Elaine Formosa, Denise Magro, Rosalie Pocock, James |
Keywords: | Hepatitis B -- Diagnosis Cell surface antigens Clinical medicine -- Case studies |
Issue Date: | 2013 |
Publisher: | Open Journal System |
Citation: | Gerada, J., Borg, E., Formosa, D., Magro, R., & Pocock, J. (2013). Tenofovir as rescue therapy following clinical failure to Lamivudine in severe acute hepatitis B. Mediterranean Journal of Hematology and Infectious Diseases, 5(1), 1-5. |
Abstract: | Acute hepatitis B (AHB) is a self-limiting condition in more than 95% of cases. Treatment is however recommended in patients with severe AHB (<1% of cases), aiming to prevent liver failure and death. Various nucleos(t)ide analogues (NA) have been found to be effective in severe AHB, although NA-resistant strains causing AHB have been also recently reported. The use of tenofovir in severe AHB has only been described in 3 cases (1 adult and 1 infant with HBV mono-infection, 1 adult with HBV/HIV co-infection). We hereby report a 47-year-old treatment-naïve male, who developed severe AHB and was initially treated with lamivudine (LMV). Initial rapid biochemical response was followed by biochemical breakthrough after 9 days, suggesting LMV resistance. Rescue therapy with ‘add-on’ tenofovir brought about a sustained improvement in biochemical, serological and virological markers until HBsAg was lost after 4 months. Thus, this is the second adult HBV mono-infected patient, who responded successfully to tenofovir in severe AHB. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/49310 |
Appears in Collections: | Scholarly Works - FacM&SMed |
Files in This Item:
File | Description | Size | Format | |
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Tenofovir_as_rescue_therapy_following_clinical_failure_to_lamivudine_in_severe_acute_hepatitis_B.pdf | 370.15 kB | Adobe PDF | View/Open |
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