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Title: | Rapid point-of-care CYP2C19*2 genotyping to personalise antiplatelet therapy in patients undergoing coronary stenting |
Authors: | Wirth, Francesca Xuereb, Robert G. Fenech, Albert Azzopardi, Lilian M. |
Keywords: | Blood platelet disorders Blood platelets -- Aggregation Clopidogrel Coronary arteries -- Stenosis Point-of-care testing -- Evaluation |
Issue Date: | 2017-01 |
Publisher: | University of Malta. Department of Pharmacy |
Citation: | Wirth, F., Xuereb, R. G., Fenech, A., & Azzopardi, L. M. (2017, January). Rapid point-of-care CYP2C19*2 genotyping to personalise antiplatelet therapy in patients undergoing coronary stenting. Poster session presented at the Festival of Genomics, London, UK. |
Abstract: | A poster presentation regarding rapid point-of-care CYP2C19*2 genotyping to personalise antiplatelet therapy in patients undergoing coronary stenting. Background: The CYP2C19 loss-of-function (LoF) *2 variant allele impairs clopidogrel bioactivation and increases the risk of thrombotic complications after coronary stenting due to decreased response to clopidogrel. Since about 50% of major adverse cardiac events occur within the first two days after coronary stenting, a rapid CYP2C19*2 genotype result is important to individualise antiplatelet therapy at the start of treatment. Guidelines for CYP2C19 genotype and clopidogrel therapy recommend that *2 allele carriers should be prescribed an alternative antiplatelet agent to clopidogrel, such as prasugrel or ticagrelor, provided there is no contra-indication. Aim: To apply a pharmacist-led process to personalise antiplatelet therapy guided by CYP2C19*2 genotype in patients undergoing coronary stenting using a rapid point-of-care (POC) genotyping system. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/49912 |
Appears in Collections: | Scholarly Works - FacM&SPha |
Files in This Item:
File | Description | Size | Format | |
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Rapid_point_of_care_CYP2C19_2_genotyping_to_personalise_antiplatelet_therapy_in_patients _undergoing_coronary_stenting_2017.pdf | 865.42 kB | Adobe PDF | View/Open |
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