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https://www.um.edu.mt/library/oar/handle/123456789/50311
Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Houston, Peter | - |
dc.contributor.author | Olar, Adrian | - |
dc.contributor.author | Cachia, David | - |
dc.date.accessioned | 2020-01-10T10:23:12Z | - |
dc.date.available | 2020-01-10T10:23:12Z | - |
dc.date.issued | 2019-12 | - |
dc.identifier.citation | Houston, P., Olar, A., & Cachia, D. (2019). Glioblastoma with leptomeningeal dissemination. Malta Medical Journal, 31(3), 34-38. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/50311 | - |
dc.description.abstract | Here we report a case of glioblastoma (GB) with leptomeningeal dissemination (LMD) in a 21 year old female presenting with generalized tonic-clonic seizures. After a brain MRI confirmed a non-enhancing left frontal lobe mass, histopathological examination and molecular analysis showed a glioblastoma with features of gliosarcoma that was an IDH wild type, MGMT unmethylated, TERT amplified tumor. She received standard care with combined chemoradiation with temozolomide and targeted radiation. MRI showing disease progression prompted the addition of bevacizumab after which the patient quickly deteriorated and died eight months after initial presentation. Incidence of LMD is an uncommon occurrence and associated with a significant decrease in overall survival when diagnosed at initial presentation. More research is needed to determine what role histopathologic variants and molecular profile plays in prognosis and treatment. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | University of Malta. Medical School | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Glioblastoma multiforme -- Case studies | en_GB |
dc.subject | Gliosarcoma | en_GB |
dc.subject | Glioblastoma multiforme -- Patients | en_GB |
dc.title | Glioblastoma with leptomeningeal dissemination | en_GB |
dc.type | article | en_GB |
dc.type | report | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.publication.title | Malta Medical Journal | en_GB |
Appears in Collections: | MMJ, Volume 31, Issue 3 MMJ, Volume 31, Issue 3 |
Files in This Item:
File | Description | Size | Format | |
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MMJ31(3)A6.pdf | 1.24 MB | Adobe PDF | View/Open |
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