Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/50555| Title: | Development of a greener selective acylation method for steroids |
| Authors: | Cioffi, Darren Sammut Bartolo, Nicolette Ferrito, Victor Vella, Janis Serracino-Inglott, Anthony |
| Keywords: | Acylation Drugs -- Synthesis Organic solvents -- Environmental aspects Dichloromethane Ethyl acetate Pharmaceutical chemistry |
| Issue Date: | 2016-04 |
| Publisher: | University of Malta. Department of Pharmacy |
| Citation: | Cioffi, D., Sammut Bartolo, N., Ferrito, V., Vella, J., & Serracino-Inglott, A. (2016, April). Development of a greener selective acylation method for steroids. Poster session presented at the 10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Glasgow, UK. |
| Abstract: | A poster presentation regarding the development of a greener selective acylation method for steroids. Introduction: The pharmaceutical industry is one of the largest consumers of organic solvents. Solvent selection in drug synthesis is a fundamental step as it affects the yield, solubility and impurity profile of the product being synthesised. Pharmaceutical manufacturers aim at reducing solvent use by minimising the number of synthetic steps, increasing solvent recycling and replacing organic solvents with novel greener alternatives. Aim: To find and use an alternative solvent to dichloromethane in order to develop a greener selective acylation method for the synthesis of the 17ɑ,21-diester steroid. |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/50555 |
| Appears in Collections: | Scholarly Works - FacM&SPha |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Development_of_a_greener_selective_acylation_method_for_steroids_2016.pdf | 592.68 kB | Adobe PDF | View/Open |
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