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https://www.um.edu.mt/library/oar/handle/123456789/53889| Title: | L-lactate reduces ischemic white matter injury and modulates HCA1 oligodendrocyte expression in an in vivo mouse model of focal ischemia |
| Authors: | Valentino, Mario Vella, J. Zammit, R. Zammit, Christian |
| Keywords: | Transient ischemic attack White matter Oligodendroglia Glucose -- Metabolism Metabolic syndrome Brain -- Research Axons -- Diseases |
| Issue Date: | 2018 |
| Publisher: | University of Malta. Medical School |
| Citation: | Valentino, M., Vella, J., Zammit, R., & Zammit, C. (2018). L-lactate reduces ischemic white matter injury and modulates HCA1 oligodendrocyte expression in an in vivo mouse model of focal ischemia. Malta Medical Journal, 30, 154 |
| Abstract: | L-lactate is a metabolite that is oxidized preferentially to glucose under conditions of high metabolic stress. The discovery and localization of the lactate receptor HCA1 in various brain regions suggests that lactate is additionally an important signaling molecule in the brain. Lactate is neuroprotective in various ischemia paradigms, reduces axonal injury in vitro and is avidly utilized by oligodendrocytes (OLs). The protective potential of L-lactate to reduce white matter (WM) injury in a mouse stroke model was investigated. |
| URI: | https://www.um.edu.mt/library/oar/handle/123456789/53889 |
| Appears in Collections: | Scholarly Works - FacM&SPB |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| L_lactate_reduces_ischemic_white_matter_injury_and_modulates_HCA1_oligodendrocyte_expression_in_an_in_vivo_mouse_model_of_focal_ischemia.pdf | 86 kB | Adobe PDF | View/Open |
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