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DC Field | Value | Language |
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dc.date.accessioned | 2020-04-16T08:16:25Z | - |
dc.date.available | 2020-04-16T08:16:25Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Caruana, A. (2012). Determination of an age-specific T-cell subset reference interval by flow cytometry for the Maltese population (Bachelor's dissertation). | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/54292 | - |
dc.description | B.SC.(HONS)APP.BIOMED.SCI. | en_GB |
dc.description.abstract | Peripheral blood lymphocyte subsets in healthy individuals vary according to age, and the extent of such variation tends to differ according to race (Shearer et al., 2003). Currently, the reference values applied for Maltese patients are those established by centres abroad. Due to any discrepancies in reference ranges because of racial differences (Jentsch- Ullrich, Koenigsmann, Mohren, & Franke, 2005), aT-cell subset reference interval should be established based on the Maltese population, in order to allow a more accurate evaluation of the patient's immune system. The aim of this study is to establish an age-specific T-cell subset reference interval specifically for the Maltese population. This study has analysed T- cell lymphocyte subsets of a representative number of healthy individuals within 5 strata of different age groups. The samples were analysed by a 4 - colour dual laser FACSCalibur flow cytometer (BD Immunocytometry Systems, San Jose, CA), and staining was carried out using a combination of fluorochrome conjugated monoclonal antibodies. The distribution of results was assessed using descriptive statistics and a comparison of means was performed. Finally, an age-specific reference interval was defined. The study shows that an age- and region-specific reference interval should be applied to the Maltese population when evaluating a person's immune status. | en_GB |
dc.language.iso | en | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | T cells | en_GB |
dc.subject | Flow cytometry -- Methods -- Malta | en_GB |
dc.subject | Lymphocytes | en_GB |
dc.subject | Patients -- Malta | en_GB |
dc.subject | Cytometry | en_GB |
dc.title | Determination of an age-specific T-cell subset reference interval by flow cytometry for the Maltese population. | en_GB |
dc.type | bachelorThesis | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder | en_GB |
dc.publisher.institution | University of Malta | en_GB |
dc.publisher.department | Faculty of Health Sciences. Department of Applied Biomedical Science | en_GB |
dc.contributor.supervisor | Brincat, Patricia | - |
dc.contributor.supervisor | Camilleri, David James | - |
dc.description.reviewed | N/A | en_GB |
dc.contributor.creator | Caruana, Abigail | - |
Appears in Collections: | Dissertations - FacHSc - 2012 Dissertations - FacHScABS - 2012 |
Files in This Item:
File | Description | Size | Format | |
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Caruana_Abigail_Determination of an Age-Specific T -Cell Subset Reference Interval by Flow Cytometry for the Maltese Population.PDF Restricted Access | 6.43 MB | Adobe PDF | View/Open Request a copy |
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