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DC Field | Value | Language |
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dc.contributor.author | Mifsud, Simon | - |
dc.contributor.author | Schembri, Emma Louise | - |
dc.contributor.author | Fava, Stephen | - |
dc.date.accessioned | 2020-06-08T10:10:26Z | - |
dc.date.available | 2020-06-08T10:10:26Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Mifsud, S., Schembri, E. L., & Fava, S. (2019). A case of severe relapsing sulphonylurea-induced hypoglycaemia. BMJ Case Reports CP, 12(12). | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/57543 | - |
dc.description.abstract | The authors report a case of a 64-year-old woman who was diagnosed with severe relapsing sulphonylurea-induced hypoglycaemia. Sulphonylureas are frequently used in patients with type 2 diabetes mellitus. They promote insulin secretion independent of the prevailing glucose level and thus are associated with an increased risk of hypoglycaemia. In patients with adequate renal function, gliclazide's effect lasts 10-24 hours and it is usually completely eliminated within 144 hours postdose. Since our patient suffered from chronic kidney disease, gliclazide's effect was prolonged and she was experiencing spontaneous hypoglycaemic episodes up to 21 days postomission of gliclazide. This case highlights two important aspects. Primarily, the prolonged effect of sulphonylureas in patients with impaired renal function, hence highlighting the need to be cautious prior to prescribing sulphonylureas in such patients. Secondly, the importance of prolonged observation of patients on sulphonylureas even after the initial hypoglycaemic event is corrected, due to the extended effects of such drugs. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | BMJ | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Hypoglycemia -- Case studies | en_GB |
dc.subject | Hypoglycemic agents | en_GB |
dc.subject | Blood sugar monitoring | en_GB |
dc.subject | Diabetes -- Complications | en_GB |
dc.subject | Diabetes Mellitus, Type 2 | en_GB |
dc.subject | Insulin | en_GB |
dc.subject | Kidneys -- Diseases -- Patients -- Care | en_GB |
dc.title | A case of severe relapsing sulphonylurea-induced hypoglycaemia | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.1136/bcr-2019-231368 | - |
dc.publication.title | BMJ Case Reports | en_GB |
Appears in Collections: | Scholarly Works - FacM&SMed |
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A_case_of_severe_relapsing_sulphonylurea_induced_hypoglycaemia_2019.pdf Restricted Access | 556.13 kB | Adobe PDF | View/Open Request a copy |
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