1. OAR@UM
  2. Faculty of Medicine and Surgery
  3. Malta Medical Journal
  4. Malta Medical Journal, 2002-
  5. 2005
  6. MMJ, Volume 17, Issue 2
Please use this identifier to cite or link to this item: https://www.um.edu.mt/library/oar/handle/123456789/578
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dc.contributor.authorPullicino, Edgar-
dc.date.accessioned2014-12-04T14:31:38Z-
dc.date.available2014-12-04T14:31:38Z-
dc.date.issued2005-
dc.identifier.citationMalta Medical Journal. 2005, Vol.17(2), p. 9-12en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar//handle/123456789/578-
dc.description.abstractThe cloning of the genome of the Hepatitis C virus (HCV) in 1989 provided sensitive screening tools and specific diagnostic assays which helped health workers to limit viral spread and scientists to design effective anti-viral agents. The uncorrected intrinsic error rate of HCV's key replicating enzyme (RNAdependent RNA polymerase) leads to antigenically different'"quasispecies" which allow the virus to escape immune recognition by the host and leads to an ill-sustained clearance of virus by T lymphocytes. This article discusses the factors which may lead to progressive liver fibrosis and provides a theoretical framework for the selection of patients for viral eradication using pegylated preparations of recombinant interferon in conjunction with the oral antiviral ribavarine.en_GB
dc.language.isoenen_GB
dc.publisherMalta Medical Journalen_GB
dc.rightsinfo:eu-repo/semantics/openAccessen_GB
dc.subjectHepatitis C -- Pathogenesisen_GB
dc.subjectFibrosis -- Liveren_GB
dc.subjectHepatitis C -- Treatmenten_GB
dc.subjectLiver -- Cirrhosisen_GB
dc.titleThe Hepatitis C virus : your part in its downfall : getting to know the virus and its hosten_GB
dc.typearticleen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.description.reviewedpeer-reviewed-
Appears in Collections:MMJ, Volume 17, Issue 2
MMJ, Volume 17, Issue 2
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