The axolotl model for cancer research : a mini-review

Abstract

The Mexican axolotl (Ambystoma mexicanum) is one of the most widely used laboratory animals for research. It is able to regenerate multiple structures including the limbs, jaws, tail, spinal cord and skin among other organs. The mechanisms governing regeneration, wound healing, development, and cancer formation are closely linked. There is increasing evidence highlighting the common signalling pathways which link to cancer growth and regeneration whereby dysregulation of the well-balanced and coordinated process of regeneration leads to cancer. This review aims to highlight the regenerative capacity of axolotls and identify how the active molecules from regeneration extracts could lead to major benefits, with directions on how to develop therapeutic approaches for cancer treatment in humans.