Analysis of dermal ageing pathways and resulting anti-ageing interventions

Abstract

Cutaneous ageing is a multifactorial process classically divided into intrinsic and extrinsic ageing, with UV radiation being the main culprit of premature skin ageing. Currently, a number of treatment strategies exist to delay and treat skin ageing, such as systemic or topical use of antioxidants, retinoids and hormone replacement therapy. Other therapies to decrease existing skin wrinkles include chemical peels, botulinum toxins, dermal fillers and visible light devices. Among others, emerging treatment strategies include anti-advanced glycation end-products, oestrogen receptor-β, growth factors, cytokines, and anti-inflammatory agents. The trend is to develop treatments which are effective, less invasive and with few side-effects.