Title: | Tractography dissection variability : what happens when 42 groups dissect 14 white matter bundles on the same dataset? |
Authors: | Schilling, Kurt G. Rheault, François Petit, Laurent Hansen, Colin B. Nath, Vishwesh Yeh, Fang-Cheng Girard, Gabriel Barakovic, Muhamed Rafael-Patino, Jonathan Yu, Thomas Fischi-Gomez, Elda Clark, Chris A. Zhang, Fan Makris, Nikos Golby, Alexandra Rathi, Yogesh O’Donnell, Lauren J. Xia, Yihao Aydogan, Dogu Baran Shi, Yonggang Guerreiro Fernandes, Francisco Gandini Wheeler-Kingshott, Claudia A.M. Raemaekers, Mathijs Warrington, Shaun Michielse, Stijn Ramírez-Manzanares, Alonso Concha, Luis Aranda, Ramón Rivera Meraz, Mariano Lerma-Usabiaga, Garikoitz Roitman, Lucas Fekonja, Lucius S. D’Angelo, Egidio Calarco, Navona Joseph, Michael Nakua, Hajer Voineskos, Aristotle N. Karan, Philippe Grenier, Gabrielle Haitz Legarreta, Jon Adluru, Nagesh Nair, Veena A. Prabhakaran, Vivek Palesi, Fulvia Alexander, Andrew L. Kamagata, Koji Saito, Yuya Uchida, Wataru Andica, Christina Masahiro, Abe Bayrak, Roza G. Savini, Giovanni Rolandi, Nicolò Guevara, Pamela Houenou, Josselin López-López, Narciso Mangin, Jean-François Pouponhhh, Cyril Pizzolato, Marco Román, Claudio Vázquez, Andrea Maffei, Chiara Arantes, Mavilde Andrade, José Paulo Silva, Susana Maria Raja, Rajikha Calhoun, Vince D. Caverzasi, Eduardo Sacco, Simone Ocampo-Pineda, Mario Lauricella, Michael Pestilli, Franco Bullock, Daniel Zhan, Yang Brignoni-Perez, Edith Lebel, Catherine Reynolds, Jess E. Nestrasil, Igor Labounek, René Lenglet, Christophe Schiavij, Simona Paulson, Amy Aulicka, Stefania Heilbronner, Sarah Heuer, Katja Anderson, Adam W. Landman, Bennett A. Descoteaux, Maxime Canales-Rodríguez, Erick J. Daducci, Alessandro Granziera, Cristina Innocenti, Giorgio Thiran, Jean-Philippe Mancini, Laura Wastling, Stephen Cocozza, Sirio Petracca, Maria Pontillo, Giuseppe Mancini, Matteo Vos, Sjoerd B. Vakharia, Vejay N. Duncan, John S. Melero, Helena Manzanedo, Lidia Sanz-Morales, Emilio Peña-Melián, Ángel Calamante, Fernando Attyé, Arnaud Cabeen, Ryan P. Korobova, Laura Toga, Arthur W. Ambili Vijayakumari, Anupa Parker, Drew Verma, Ragini Radwan, Ahmed Sunaert, Stefan Emsell, Louise De Luca, Alberto Leemans, Alexander Bajada, Claude J. Haroon, Hamied A. Azadbakht, Hojjatollah Chamberland, Maxime Genc, Sila Tax, Chantal M. W. Yeh, Ping-Hong Srikanchana, Rujirutana Mcknight, Colin Yang, Joseph Yuan-Mou Chen, Jian Kelly, Claire E. Yeh, Chun-Hung Cochereau, Jerome Maller, Jerome J. Welton, Thomas Almairac, Fabien Seunarine, Kiran K. |
Keywords: | Diffusion Tensor Imaging Brain -- Magnetic resonance imaging Brain -- Imaging White matter Central nervous system |
Issue Date: | 2020 |
Publisher: | Cold Spring Harbor Laboratory |
Citation: | Schilling, K.G., Rheault, F., Petit, L., Hansen, C. B., Nath, V., Yeh, F.C.,….Descoteaux, M. (2020). Tractography dissection variability: what happens when 42 groups dissect 14 white matter bundles on the same dataset? bioRxiv doi: 2020.10.07.321083. |
Abstract: | White matter bundle segmentation using diffusion MRI fiber tractography has become the method of choice to identify white
matter fiber pathways in vivo in human brains. However, like other analyses of complex data, there is considerable variability in
segmentation protocols and techniques. This can result in different reconstructions of the same intended white matter pathways,
which directly affects tractography results, quantification, and interpretation. In this study, we aim to evaluate and quantify the
variability that arises from different protocols for bundle segmentation. Through an open call to users of fiber tractography,
including anatomists, clinicians, and algorithm developers, 42 independent teams were given processed sets of human wholebrain
streamlines and asked to segment 14 white matter fascicles on six subjects. In total, we received 57 different bundle
segmentation protocols, which enabled detailed volume-based and streamline-based analyses of agreement and disagreement
among protocols for each fiber pathway. Results show that even when given the exact same sets of underlying streamlines, the
variability across protocols for bundle segmentation is greater than all other sources of variability in the virtual dissection
process, including variability within protocols and variability across subjects. In order to foster the use of tractography bundle
dissection in routine clinical settings, and as a fundamental analytical tool, future endeavors must aim to resolve and reduce
this heterogeneity. Although external validation is needed to verify the anatomical accuracy of bundle dissections, reducing
heterogeneity is a step towards reproducible research and may be achieved through the use of standard nomenclature and
definitions of white matter bundles and well-chosen constraints and decisions in the dissection process. |
URI: | https://www.um.edu.mt/library/oar/handle/123456789/61531 |
Appears in Collections: | Scholarly Works - FacM&SPB
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