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dc.date.accessioned2021-01-13T09:07:24Z-
dc.date.available2021-01-13T09:07:24Z-
dc.date.issued2020-
dc.identifier.citationMicallef, K.L. (2020). Vitamin D receptor (VDR) polymorphisms & metabolic health status in a Maltese cohort (Bachelor's dissertation).en_GB
dc.identifier.urihttps://www.um.edu.mt/library/oar/handle/123456789/67077-
dc.descriptionB.SC.MEDICAL BIOCHEMISTRYen_GB
dc.description.abstractBackground: Several studies have investigated the association between vitamin D receptor (VDR) variants and the risk of cardiometabolic complications. The pleiotropic action of the VDR in extra-skeletal tissues gives physiologic plausibility to the associations between VDR variants and metabolic health, particularly in obese individuals. Whilst multiple conflicting findings have been reported, clinical data has shown that despite an increase in physical activity and nurturing healthier dietary choices, there are individuals who do not benefit from lifestyle changes. This study aims to replicate the association between common VDR variants and obesity risk in a wellcharacterised Maltese cohort stratified into metabolically healthy and unhealthy obese phenotypes; a hypothesis that has never been investigated in the Maltese population. Methods: A cross-sectional case-control study involving 480 working age Maltese adults was conducted. The cohort was stratified into four different body composition phenotypes based on BMI and metabolic syndrome components. Four VDR polymorphisms [FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232) and TaqI (rs731236)] were genotyped by PCR-RFLP, and the association with metabolic health phenotypes was investigated. Results: The VDR TaqI C/C genotype was associated with higher odds of obesity, independent of metabolic health status. A higher frequency of the BsmI G/A and TaqI T/C genotypes was observed in the metabolically healthy obese (MHO) subgroup when compared to the metabolically unhealthy obese (MUHO) subgroup. VDR haplotype block 2 was associated with a significantly higher odds of MHO. Conclusions: Our results suggest that in the high prevalence Maltese population, VDR polymorphisms are associated with obesity and metabolic health status. Future studies should further investigate the overall effect of multiple variants associated with obesity phenotypes and relate genotypes with the longitudinal progression of obesity to assess the dynamic nature of metabolic health.en_GB
dc.language.isoenen_GB
dc.rightsinfo:eu-repo/semantics/restrictedAccessen_GB
dc.subjectObesity -- Maltaen_GB
dc.subjectCardiovascular system -- Diseases -- Maltaen_GB
dc.subjectMetabolism -- Disorders -- Maltaen_GB
dc.subjectNuclear receptors (Biochemistry)en_GB
dc.subjectVitamin Den_GB
dc.subjectGenetic polymorphisms -- Maltaen_GB
dc.titleVitamin D receptor (VDR) polymorphisms & metabolic health status in a Maltese cohorten_GB
dc.typebachelorThesisen_GB
dc.rights.holderThe copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder.en_GB
dc.publisher.institutionUniversity of Maltaen_GB
dc.publisher.departmentFaculty of Medicine and Surgery. Department of Physiology and Biochemistryen_GB
dc.description.reviewedN/Aen_GB
dc.contributor.creatorMicallef, Kay Lee-
Appears in Collections:Dissertations - FacM&S - 2020
Dissertations - FacM&SPB - 2020

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