Please use this identifier to cite or link to this item:
https://www.um.edu.mt/library/oar/handle/123456789/77918
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.date.accessioned | 2021-07-02T10:48:36Z | - |
dc.date.available | 2021-07-02T10:48:36Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Zarb, C. M. (2012). Identifying compounds that enhance the resilience of isolated neuronal mitochondria against dysfunction induced by Aß42 and tau oligomers (Master's dissertation). | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/77918 | - |
dc.description | M.SC.PHARMACOLOGY | en_GB |
dc.description.abstract | The oligomeric intraneuronal accumulation of amyloid beta AB42 (AB42 ) and Tau has been directly linked to Alzheimer's Disease (AD) pathology and progression. In particular, mounting evidence indicates that oligomer-induced mitochondrial abnormalities are early occurrences, preceding neurological pathology and clinical symptoms characteristic of AD. Perforation of mitochondrial membranes leads to the release of pro-apoptotic proteins such as cytochrome c into the cellular cytosol, triggering neuronal apoptosis. The main aims of the study were to determine any effects of Ab42 and Tau aggregates on mitochondrial membranes and subsequently identify mitochondrial-protective compounds. The rationale behind the study was to gain further insight as to the mechanisms involved in AbTau induced mito-toxicity, and identify potential candidates for effective mitochondrial drugs in AD. | en_GB |
dc.language.iso | en | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Mitochondria | en_GB |
dc.subject | Oligomers | en_GB |
dc.subject | Conjugated oligomers | en_GB |
dc.title | Identifying compounds that enhance the resilience of isolated neuronal mitochondria against dysfunction induced by Aß42 and tau oligomers | en_GB |
dc.type | masterThesis | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.publisher.institution | University of Malta | en_GB |
dc.publisher.department | Faculty of Laws. Department of Commercial Law | en_GB |
dc.description.reviewed | N/A | en_GB |
dc.contributor.creator | Zarb, Claire M (2012) | - |
Appears in Collections: | Dissertations - FacM&S - 2012 Dissertations - FacM&SCPT - 2012 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
M.SC.PHARMACOLOGY_Zarb_Claire_ M_2012.pdf Restricted Access | 9.44 MB | Adobe PDF | View/Open Request a copy |
Items in OAR@UM are protected by copyright, with all rights reserved, unless otherwise indicated.