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DC Field | Value | Language |
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dc.date.accessioned | 2021-07-05T09:50:43Z | - |
dc.date.available | 2021-07-05T09:50:43Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Vella, T. (2012). Interactions between valproate and olanzapine/quetiapine in bipolar disorder (Master's dissertation). | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/77988 | - |
dc.description | M.SC.PHARMACOLOGY | en_GB |
dc.description.abstract | A combination of valproate with an atypical antipsychotic provides synergistic mood stabilizing, anti-depressant and anti-psychotic action in bipolar and schizoaffective disorders. Reports of rare, but serious, adverse drug reactions occurring on the addition of valproic acid to olanzapine and quetiapine monotherapy indicate a possible pharmacokinetic or pharmacodynamic drug-drug interaction. Some studies have shown that valproate affects drug metabolising enzymes responsible for the metabolism of olanzapine and quetiapine, resulting in altered antipsychotic plasmsa concentrations and interfering with clinical efficacy and toxicity. The aim of this study was thus to recruit patients on a combination of valproate/olanzapine or valproate/quetiapine to assess the possible effect of valproate on the plasma concentrations of these antipsychotics by comparing the drug concentrations in these patients with control groups of patients on quetiapine or olanzapine monotherapy. | en_GB |
dc.language.iso | en | en_GB |
dc.rights | info:eu-repo/semantics/restrictedAccess | en_GB |
dc.subject | Manic-depressive persons | en_GB |
dc.subject | Valproic acid | en_GB |
dc.subject | Olanzapine | en_GB |
dc.title | Interactions between valproate and olanzapine/quetiapine in bipolar disorder | en_GB |
dc.type | masterThesis | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.publisher.institution | University of Malta | en_GB |
dc.publisher.department | Faculty of Medicine and Surgery. Department of Clinical Pharmacology and Therapeutics | en_GB |
dc.description.reviewed | N/A | en_GB |
dc.contributor.creator | Vella, Thomas (2012) | - |
Appears in Collections: | Dissertations - FacM&S - 2012 Dissertations - FacM&SCPT - 2012 |
Files in This Item:
File | Description | Size | Format | |
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M.SC.PHARMACOLOGY_Vella_Thomas_2012.pdf Restricted Access | 8.49 MB | Adobe PDF | View/Open Request a copy |
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