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DC Field | Value | Language |
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dc.contributor.author | Sabol, Maja | - |
dc.contributor.author | Calleja-Agius, Jean | - |
dc.contributor.author | Di Fiore, Riccardo | - |
dc.contributor.author | Suleiman, Sherif | - |
dc.contributor.author | Ozcan, Sureyya | - |
dc.contributor.author | Ward, Mark P. | - |
dc.contributor.author | Ozretić, Petar | - |
dc.date.accessioned | 2021-10-13T14:09:14Z | - |
dc.date.available | 2021-10-13T14:09:14Z | - |
dc.date.issued | 2021 | - |
dc.identifier.citation | Sabol, M., Calleja-Agius, J., Di Fiore, R., Suleiman, S., Ozcan, S., Ward, M. P., & Ozretić, P. (2021). (In)Distinctive role of long non-coding RNAs in common and rare ovarian cancers. Cancers, 13(20), 5040. | en_GB |
dc.identifier.uri | https://www.um.edu.mt/library/oar/handle/123456789/82099 | - |
dc.description.abstract | Rare ovarian cancers (ROCs) are OCs with an annual incidence of fewer than 6 cases per 100,000 women. They affect women of all ages, but due to their low incidence and the potential clinical inexperience in management, there can be a delay in diagnosis, leading to a poor prognosis. The underlying causes for these tumors are varied, but generally, the tumors arise due to alterations in gene/protein expression in cellular processes that regulate normal proliferation and its checkpoints. Dysregulation of the cellular processes that lead to cancer includes gene mutations, epimutations, non-coding RNA (ncRNA) regulation, posttranscriptional and posttranslational modifications. Long non-coding RNA (lncRNA) are defined as transcribed RNA molecules, more than 200 nucleotides in length which are not translated into proteins. They regulate gene expression through several mechanisms and therefore add another level of complexity to the regulatory mechanisms affecting tumor development. Since few studies have been performed on ROCs, in this review we summarize the mechanisms of action of lncRNA in OC, with an emphasis on ROCs. | en_GB |
dc.language.iso | en | en_GB |
dc.publisher | MDPI AG | en_GB |
dc.rights | info:eu-repo/semantics/openAccess | en_GB |
dc.subject | Rare diseases | en_GB |
dc.subject | Ovaries -- Cancer | en_GB |
dc.subject | RNA -- Analysis | en_GB |
dc.title | (In)Distinctive role of long non-coding RNAs in common and rare ovarian cancers | en_GB |
dc.type | article | en_GB |
dc.rights.holder | The copyright of this work belongs to the author(s)/publisher. The rights of this work are as defined by the appropriate Copyright Legislation or as modified by any successive legislation. Users may access this work and can make use of the information contained in accordance with the Copyright Legislation provided that the author must be properly acknowledged. Further distribution or reproduction in any format is prohibited without the prior permission of the copyright holder. | en_GB |
dc.description.reviewed | peer-reviewed | en_GB |
dc.identifier.doi | 10.3390/cancers13205040 | - |
Appears in Collections: | Scholarly Works - FacM&SAna |
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(In)Distinctive_role_of_long_non-coding_RNAs_in_common_and_rare_ovarian_cancers_2021.pdf | 820.83 kB | Adobe PDF | View/Open |
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